The formation of 2,5-diketopiperazine (DKP) with a bicyclic structure is one of the most detrimental side reactions and degradation pathways affecting peptide synthesis. Despite its crucial role as a versatile building block in drug discovery, the formation of DKP reactions is ...Learn More

The nature of the cell death process (non-inflammatory or pro-inflammatory) dictates the response of neighboring cells, which in turn determines important systemic physiological outcomes. Pyroptosis, or caspase 1-dependent cell death, is inflammatory in nature, triggered by ...Learn More

Drug Metabolism and Pharmacokinetics (DMPK) is a core discipline in drug development that takes into account the biotransformation and other pharmacokinetic properties of drug compounds to assess drug safety. DMPK studies allow drug developers to experimentally evaluate the ...Learn More

Ion channels are involved in a variety of fundamental physiological processes, and their malfunction leads to a variety of human diseases. Thus, ion channels represent an attractive class of drug targets and an important class of off-target sites for in vitro pharmacological ...Learn More

With the advent of next-generation sequencing (NGS) technologies, variants underpinning rare genetic diseases are being discovered at an accelerated rate. However, many rare conditions lack effective treatments due to poor understanding of their pathophysiology. Therefore, there ...Learn More