Yuan Liu

Yuan Liu, M.D., Ph.D., joined the Department of Chemistry and Biochemistry at Florida International University (FIU) in 2010 as a faculty member. Her research interest focuses on understanding the molecular mechanisms by which DNA damage and repair modulates genome and epigenome stability and their roles in development, prevention, and treatment of human cancer and neurodegenerative diseases such as Huntington’s disease and Friedreich’s ataxia, among others. Her research interests also include DNA repair as biomarkers for diagnosis, treatment and prognosis of cancer and human neurodegeneration, and drug discoveries of DNA repair inhibitors as treatments of human diseases. Dr. Liu’s research has been supported by the National Institutes of Health. Her work has been published in numerous journals including Nature, Molecular Cell, PNAS, Nucleic Acids Research, and DNA Repair. Dr. Liu was awarded the Top Scholar of Florida International University in 2014.

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Chemistry and Biochemistry, Biomolecular Sciences Institute, Florida International University

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  1. Masi A, Sabbia A, Ferreri C, Manoli F, Lai Y, Laverde E, Liu Y, Krokidis MG, Chatgilialoglu C, Faraone Mennella MR (2019). Cells. 8(2). pii: E116. doi: 10.3390/cells8020116.

  2. Wen Z, Peng J, Tuttle PR, Ren Y, Garcia C, Debnath D, Rishi S, Hanson C, Ward S, Kumar A, Liu Y, Zhao W, Glazer PM, Liu Y, Sevilla MD, Adhikary A, Wnuk SF (2018). Electron-Mediated Aminyl and Iminyl Radicals from C5 Azido-Modified Pyrimidine Nucleosides Augment Radiation Damage to Cancer Cells. Organic Letters. 20 (23), pp 7400–7404.

  3. Lai Y, Weizmann Y, Liu Y** (2018) The deoxyribose phosphate lyase of DNA polymerase β suppresses a processive DNA synthesis to prevent trinucleotide repeat instability. Nucleic Acids Res. 46(17):8940-8952.

  4. Suzol, SH, Howlader, AH, Wen Z, Ren, Y, Laverde EE, Garcia C, Liu, Y and Wnuk SF (2018) Pyrimidine nucleosides with a reactive (β-chlorovinyl)sulfone or (β-keto)sulfone group at the C5 position, their Reactions with nucleophiles and electrophiles, and their polymerase-catalyzed incorporation into DNA. ACS Omega, 2018, 3 (4), pp 4276–4288 doi: 10.1021/acsomega.8b00584

  5. Beaver JM, Lai Y, Rolle SJ, Weng L, Greenberg MM, Liu, Y** (2018) An oxidized abasic lesion inhibits base excision repair leading to DNA strand breaks in a trinucleotide repeat tract. PLoS One 13(2):e0192148. doi: 10.1371/journal.pone.0192148.


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