Miguel Gómez Fontela
I am a genetic immunologist focused in understanding the transcriptional regulation of several immune system genes, and how their expression determines the behavior of immune system cell populations. I have been working for 6 years as a scientist, being the last 4 focused on the adaptation of CRISPR-Cas9 system for gene editing, for driving gene expression and for characterizing the proteins bound to a given region by using the enChIP technique. As part of my PhD thesis I developed a device based on laser induced forward transfer for immune system cells printing. Sharing the scientific knowledge with society is one of my major goals in parallel with the development of my scientific career. For that reason, I am managing a web blog in Spanish which shares some news and important achievements of science to the people how are interested on research and development. Now, as a part of MolecularCloud, my main goal is to share with scientist and students the novel techniques and applications that science develops every day.
Lab Information
Centro Nacional de Microbiología, Instituto de Salud Carlos III
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CRISPR-Cas9 0 immunology 0 genetics 0 transcriptional regulation 0 molecular biosciences 0 cell culture 0 western blot 0 CRISPR-interference 0 CRISPR-activation 0 nucleic acid purification 0 mouse models 0 chromatin immunoprecipitation 0 enChIP 0 LIFT 0 PCR 0
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CRISPR-Cas gene editing has been widely used for generation of knock-out models, but the insertion of specific changes in the DNA sequence through homologous directed repair (HDR) mediated editing remains challenging due to its limited efficiency and high rates of undesired ...Learn More
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In recent years there is an increasing number of cytotoxic chemotherapeutic compounds with the ability to rapidly kill dividing cancer cells in preference to non-dividing healthy cells. Nevertheless, the major drawback of chemotherapy is that, in addition to damaging the cancer ...Learn More
Recycling data obtained in 2015 indicated that only 9% of the plastic that we throw away in the garbage is effectively recycled, while 12% of total plastic ends up being incinerated and 79% accumulated in a garbage dump [1]. Recently, synthetic biology allows for the production of ...Learn More
Immune functions are not unique to hematopoietic cells, as many other cell types display basic mechanisms of pathogen defense [1-3]. The epithelium, made by epithelial cells, constitute the structure of tissues and organs in the mammalian body, creating the internal and external ...Learn More
Bacteriophages (also known as ‘phages’), which are viruses that infect bacteria, are the most abundant biological entities on the planet [1]. As a response to the constant threat of phage infection, a huge arsenal of defense mechanisms has evolved in bacterial hosts, and as a ...Learn More
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