Miguel Gómez Fontela

PhD | Molecular Biosciences. I am a genetic immunologist focused in understanding the transcriptional regulation of several immune system genes, and how their expression determines the behavior of immune system cell populations. I have been working for 6 years as a scientist, being the last 4 focused on the adaptation of CRISPR-Cas9 system for gene editing, for driving gene expression and for characterizing the proteins bound to a given region by using the enChIP technique. As part of my PhD thesis I developed a device based on laser induced forward transfer for immune system cells printing. Sharing the scientific knowledge with society is one of my major goals in parallel with the development of my scientific career. For that reason, I am managing a web blog in Spanish which shares some news and important achievements of science to the people how are interested on research and development. Now, as a part of MolecularCloud, my main goal is to share with scientist and students the novel techniques and applications that science develops every day.

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Centro Nacional de Microbiología, Instituto de Salud Carlos III

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CRISPR-Cas9 0 immunology 0 genetics 0 transcriptional regulation 0 molecular biosciences 0 cell culture 0 western blot 0 CRISPR-interference 0 CRISPR-activation 0 nucleic acid purification 0 mouse models 0 chromatin immunoprecipitation 0 enChIP 0 LIFT 0 PCR 0

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Despite the difficulties that certain countries are experiencing during the implementation of an effective vaccination strategy, the global SARS-CoV-2 pandemic has led to a collective effort for the generation of effective and safety vaccines in a very short time. At present there ...Learn More


Nanotechnology has shown an important potential in the immunotherapeutic field, as the modulation of a variety of immune processes can be achieved both in vitro and in vivo. Nanotechnology can be used to promote the immune activation or to induce tolerance depending on the ...Learn More


Antibody-based therapies are not new, as the use of these molecules to combat human diseases dates back to the 1890s. Antibodies are a key component of the immune system adaptive branch that recognizes a foreign molecule called antigen and mobilize various immune processes to ...Learn More


We are living in a new, unofficial but significant unit of geological time called Anthropocene, which is characterized by the impact that the human activity have on the planet’s climate and ecosystems [1]. Some researchers even think that Plasticene will be a better descriptor ...Learn More


Cytotoxic T lymphocytes (CTLs) are cells that belongs to the adaptive immune system which eliminate tumorigenic or pathogen-infected cells. The process by which CTLs recognize the cognate antigens presented by target cells to eliminate them is called immunosurveillance. As target ...Learn More


  1. Author: Fontela, M. G et al. ‘The Core Region of the Conserved Non-Coding Sequence 2 Enhancer Function as a Switch for Human CD69 Transcription and Its Controled Cytokine Production'. Under review.

  2. Redondo, J., Fontela, M. G et al. ‘Functional characterization of a dual enhancer/promoter regulatory element leading human CD69 expression'. Frontiers in Genetics. Accepted 8th October 2020.

  3. Coauthor: Lorente, E., Fontela, M. G et al. ‘Modulation of natural HLA-B*27:05 ligandome by ankylosing spondylitis-associated endoplasmic reticulum aminopeptidase 2 (ERAP2)'. Molecular & Cellular Proteomics, 2020, 19 (6) 994-1004. doi:10.1074/mcp.ra120.002014

  4. Coauthor: A. Márquez and Miguel G. Fontela. 'Fluorescence enhanced BA-LIFT for single cell detection and isolation'. Biofabrication. January 2020. DOI: 10.1088/1758-5090/ab6138

  5. Author: Miguel G. Fontela et al. ‘The Conserved Non-Coding Sequence 2 (CNS2) Enhances CD69 Transcription Trough Cooperation Between the Transcription Factors Oct1 and RUNX1'. Genes. August 2019. DOI: 10.3390/genes10090651

  6. Collaborator: David Canteli et al. ‘Laser-Induced Forward Transfer of silver-based pastes for metallization of photovoltaic devices. SPIE conference proceedings. DOI: https://doi.org/10.1117/12.2508975

  7. Collaborator: Laguna. T et al. ‘New insights on the transcriptional regulation of CD69 gene through a potent enhancer located in the conserved non coding sequence 2'. Molecular Immunology. March 2015. DOI:10.1016/j.molimm.2015.02.031


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