Miguel Gómez Fontela

PhD | Molecular Biosciences. I am a genetic immunologist focused in understanding the transcriptional regulation of several immune system genes, and how their expression determines the behavior of immune system cell populations. I have been working for 6 years as a scientist, being the last 4 focused on the adaptation of CRISPR-Cas9 system for gene editing, for driving gene expression and for characterizing the proteins bound to a given region by using the enChIP technique. As part of my PhD thesis I developed a device based on laser induced forward transfer for immune system cells printing. Sharing the scientific knowledge with society is one of my major goals in parallel with the development of my scientific career. For that reason, I am managing a web blog in Spanish which shares some news and important achievements of science to the people how are interested on research and development. Now, as a part of MolecularCloud, my main goal is to share with scientist and students the novel techniques and applications that science develops every day.

Lab Information

Centro Nacional de Microbiología, Instituto de Salud Carlos III

Research Area and Skills

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CRISPR-Cas9 0 immunology 0 genetics 0 transcriptional regulation 0 molecular biosciences 0 cell culture 0 western blot 0 CRISPR-interference 0 CRISPR-activation 0 nucleic acid purification 0 mouse models 0 chromatin immunoprecipitation 0 enChIP 0 LIFT 0 PCR 0


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Cytotoxic T lymphocytes (CTLs) are cells that belongs to the adaptive immune system which eliminate tumorigenic or pathogen-infected cells. The process by which CTLs recognize the cognate antigens presented by target cells to eliminate them is called immunosurveillance. As target ...Learn More

Although titanic efforts are being made for the development of treatments against the novel SARS-CoV-2 disease (COVID-19) and the approval of the recently developed vaccines by the Food and Drug Administration (FDA) and counterpart regulatory agencies such as the European ...Learn More

Coronaviruses (CoVs) are enveloped, single-stranded, positive-sense RNA viruses belonging to the Nidovirales order and responsible for causing seasonal mild respiratory illness in humans [1], although severe acute respiratory syndrome CoV (SARS-CoV) in 2002 and Middle East ...Learn More

Cancer appears from the own cells of an organism and creates a tumor microenvironment with immune evasion and immunosuppression signals capable of avoiding the immune response [1]. Immunotherapy is a medical strategy applied to the treatment of cancer based on harnessing the ...Learn More

Understanding the nature of the immune response that leads to recovery over severe disease is key to developing effective treatments for COVID-19. Coronaviruses typically induce strong inflammatory responses and associated lymphopenia [1, 2], and it has been reported that during ...Learn More

  1. Author: Fontela, M. G et al. ‘The Core Region of the Conserved Non-Coding Sequence 2 Enhancer Function as a Switch for Human CD69 Transcription and Its Controled Cytokine Production'. Under review.

  2. Redondo, J., Fontela, M. G et al. ‘Functional characterization of a dual enhancer/promoter regulatory element leading human CD69 expression'. Frontiers in Genetics. Accepted 8th October 2020.

  3. Coauthor: Lorente, E., Fontela, M. G et al. ‘Modulation of natural HLA-B*27:05 ligandome by ankylosing spondylitis-associated endoplasmic reticulum aminopeptidase 2 (ERAP2)'. Molecular & Cellular Proteomics, 2020, 19 (6) 994-1004. doi:10.1074/mcp.ra120.002014

  4. Coauthor: A. Márquez and Miguel G. Fontela. 'Fluorescence enhanced BA-LIFT for single cell detection and isolation'. Biofabrication. January 2020. DOI: 10.1088/1758-5090/ab6138

  5. Author: Miguel G. Fontela et al. ‘The Conserved Non-Coding Sequence 2 (CNS2) Enhances CD69 Transcription Trough Cooperation Between the Transcription Factors Oct1 and RUNX1'. Genes. August 2019. DOI: 10.3390/genes10090651

  6. Collaborator: David Canteli et al. ‘Laser-Induced Forward Transfer of silver-based pastes for metallization of photovoltaic devices. SPIE conference proceedings. DOI: https://doi.org/10.1117/12.2508975

  7. Collaborator: Laguna. T et al. ‘New insights on the transcriptional regulation of CD69 gene through a potent enhancer located in the conserved non coding sequence 2'. Molecular Immunology. March 2015. DOI:10.1016/j.molimm.2015.02.031

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