yanli wang
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Chinese Academy of Sciences Key Laboratory of Nucleic Acid Biology, IBP
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CRISPR-Cas system 0 Argonaut (Ago) protein-mediated RNA/DNA interference. 0
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Huang X, Sun W, Cheng Z, Chen M, Li X, Wang J, Sheng G*, Gong W* and Wang Y*. Structural basis for two metal-ion catalysis of DNA cleavage by Cas12i2. Nature Communications, 2020.10, online.
Sun W#, Yang J#, Cheng Z#, Amrani N, Liu C, Wang K, Ibraheim R, Edraki A, Huang X, Wang M, Wang J, Liu L, Sheng G, Yang Y, Lou J, Sontheimer E*, and Wang Y*. Structures of Neisseria meningitidis Cas9 Complexes in Catalytically Poised and Anti-CRISPR-Inhibited States. Molecular Cell, 2019, 76(6): 938-952.
You L, Ma J, Wang J, Artamonova D, Wang M, Liu L, Xiang H, Severinov K, Zhang X*, Wang Y*. Structure Studies of the CRISPR-Csm Complex Reveal Mechanism of Co-transcriptional Interference. Cell, 2019, 176, 239–253.
Liu L, Yin M, Wang M, Wang Y*. Phage AcrIIA2 DNA Mimicry: Structural Basis of the CRISPR and Anti-CRISPR Arms Race. Molecular Cell, 2019, 73, 611–620.
Lei J, Sheng G, Peter Pak-Hang Cheung, Wang S, Li Y, Gao X, Zhang Y*, Wang Y*, Huang X*. Two symmetric arginine residues play distinct roles in Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage, PNAS, 2019，116: 845–853.
Chang L#, Sheng G#, Zhang Y#, Shao S, Wang Y* and Sun Y*. AgoFISH: cost-effective in situ labelling of genomic loci based on DNA-guided dTtAgo protein. Nanoscale Horizons, 2019, 4:918-923.
Thavalingam A, Cheng Z, Garcia B, Huang X, Shah M, Sun W, Wang M, Harrington L, Hwang Sungwon Y, Reyes H, Sontheimer E, Doudna J, Davidson A, Moraes T*, Wang Y*, Maxwell K*. Inhibition of CRISPR-Cas9 ribonucleoprotein complex assembly by anti-CRISPR AcrIIC2. Nature Commun., 2019, 26;10(1):2806.
Yin M, Wang J, Wang M, Li X, Zhang M, Wu Q, Wang, Y. Molecular mechanism of directional CTCF recognition of a diverse range of genomic sites. Cell Research, 2017, 27(11):1365-1377.
Liu L, Li X, Ma J, Li Z, You L, Wang J, Wang M, Zhang X, Wang, Y. The Molecular Architecture for RNA-Guided RNA Cleavage by Cas13a. Cell, 2017. 170(4):714-726.
Sheng G, Gogakos T, Wang J, Zhao, H, Serganov A, Juranek S, Tuschl T, Patel D, Wang, Y. Structure/cleavage-based insights into helical perturbations at bulge sites within T. thermophilus Argonaute silencing complexes. Nucleic Acids Res. 2017, 45(15):9149-9163.
Liu L, Li X, Wang J, Yin M, Chen P, Wang M, Li J, Sheng G, Wang Y. Two Distant Catalytic Sites Are Responsible for C2c2 RNase Activities. Cell. 2017,168:121-134.
Liu L, Chen P, Wang M, Li X, Wang J, Yin M, Wang Y. C2c1-sgRNA Complex Structure Reveals RNA-guided DNA Cleavage Mechanism. Molecular Cell. 2017, 65.
Swarts D, Szczepaniak M, Sheng G, Chandradoss S, Zhu Y, Timmers E, Zhang Y, ZhaoH, Lou J, Wang Y, Joo C and Oost J. Autonomous Generation and Loading of DNA Guides by Bacterial Argonaute，Molecular Cell, 2017, 65(6):985-998.
Wang J, Ma J, Cheng Z, Meng X, You L, Wang M, Zhang X, Wang, Y. A CRISPR evolutionary arms race: structural insights into viral anti-CRISPR/Cas responses. Cell Research. 2016, 26:1165–1168.
Wang, J., Li, J., Zhao, H., Sheng, G., Wang, M., Yin, M. & Wang, Y., Structural and Mechanistic Basis of PAM-Dependent Spacer Acquisition in CRISPR-Cas System. Cell. 2015, 163: 840-853.
Zhao, H., Sheng, G., Wang, J., Wang, M., Bunkoczi, G., Gong, W., Wei, Z. & Wang, Y. “Crystal structure of the RNA-guided immune surveillance Cascade complex in Escherichia coli”, Nature. 2014, 151: 147-150.
Swarts, D. C., Makarova, K., Wang, Y., Nakanishi, K., Ketting, R., Koonin, E., Patel, D. J. & Oost, van der, J., “The evolutionary journey of Argonaute proteins”, Nature structural & molecular biology, 2014, 21: 743-753.
Swarts, D. C., Jore, M. M., Westra, E. R., Zhu, Y., Janssen, J. H., Snijders, A. P., Wang, Y., Patel, D. J., Berenguer, J., Brouns, S. J.J. & Oost, van der, J. "DNA-guided DNA interference by a prokaryotic Argonaute", Nature, 2014, 507: 258-261.
Sheng, G., Zhao, H., Wang, J., Rao, Y., Tian, W., Swarts, D. C., van der Oost, J., Patel, D. J. and Wang, Y. "Structure-based cleavage mechanism of Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage." Proc Natl Acad Sci U S A.2014, 111(2): 652-657.
Rüdel S, Wang, Y, Lenobel R, K?rner R, Hsiao HH, Urlaub H, Patel D, Meister G. Phosphorylation of human Argonaute proteins affects small RNA binding. Nucleic Acids Res.2011,39:2330-43.
Wang, Y., Ludwig J., Schuberth C., Goldeck M., Schlee M., Li H., Juranek S., Sheng G., Micura R., Tuschl T., Hartmann G., Patel D., Structural and functional insights into 5'-ppp RNA pattern recognition by the innate immune receptor RIG-I. Nat Struct Mol Biol. 2010, 17:781-7.. 2010, 17:781-7.
Wang, Y, Juranek S, Li H, Sheng G, Tuschl T, Patel DJ. Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes. Nature. 2009, 461:754-761.
Wang, Y, Juranek S, Li H, Sheng G, Tuschl T, Patel DJ. Structure of an argonaute silencing complex with a seed-containing guide DNA and target RNA duplex. Nature. 2008, 56:921-926.
Wang, Y, Sheng G, Juranek S, Tuschl T, Patel DJ., Structure of the guide-strand-containing argonaute silencing complex. Nature. 2008, 456:209-213.
Wang, Y, Liu L, Wei Z, Cheng Z, Lin Y, Gong W. Seeing the process of histidine phosphorylation in human bisphosphoglycerate mutase. J Biol Chem. 2006, 281:39642-8.
Wang, Y, Wei Z, Liu L, Cheng Z, Lin Y, Ji F, Gong W. Crystal structure of human B type phosphoglycerate mutase bound with citrate. Biochem. Biophys. Res. Commun. 2005, 331:1207-15.
Wang, Y, Wei Z, Bian Q, Cheng Z, Wan M, Liu L, Gong W，Crystal structure of human bisphosphoglycerate mutase, J. Biol. Chem. 2004, 279: 39132-8.
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