Xiangjian Zheng

Xiangjian Zheng completed Ph.D. in Molecular Medicine at Medical College of Georgia, where he studied lipid signalling in skin biology and endocrine control of blood pressure control. At present Zheng leads the lab of cardiovascular signalling at Centenary Institute, where he continued his research interest in signalling involved in the cardiovascular development and diseases, meanwhile investigating the role of endothelium in organ development and regeneration. In the recent projects, the vascular disease cerebral cavernous malformation (CCM), which causes sporadic or inherited vascular malformations in the brain that can lead to stroke, is extensively studied in his lab. The lab is currently using genetically engineered mouse model to mimic these human mutations and investigates how these genes control blood vessel formation and how their loss of function leads to vessel malformation. This research should lead to the identification of therapeutic targets for CCM and related vascular diseases.

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Centenary Institute, The University of Sydney

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Cardiovascular Development and Diseases 0 Lipid Signalling 0 Cerebral Cavernous Malformation 0

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  1. Zhou Z, RawnsleyD, Goddard L, Pan W, Cao X, Jakus Z, Zheng H, Yang J, Arthur S, WhiteheadKJ, LiD, Zhou B, Garcia BA, Zheng X* and Kahn ML*. The cerebral cavernous malformation pathway controls cardiac development via regulation of endocardial MEKK3 signaling and KLF expression. Dev Cell 32(2): 168-180 (2015)(* co-corresponding author).

  2. Zheng X, Riant F, Bergametti F, Myers CD, Tang AT, KleavelandB, Pan W, Yang J, Tounier-Reserve E and Kahn ML. Cerebral cavernous malformations arise independent of heart-of-glass receptor. Stroke 45(5): 1505-09(2014).

  3. Zheng X, Xu C, Smith AO, Stratman AN, ZouZ, KleavelandB, YuanL, Didiku C, Skuli N, ZaslavskyA, ChenM, Cheng L, DavisGE, and Kahn ML. Dynamic regulation of cerebral cavernous malformation pathway controls cardiovascular stability and growth. Dev cell 23 (2): 342-355 (2012).

  4. Choi, J., Zheng, X. (2020). Generation of Cerebral Cavernous Malformation in Neonatal Mouse Models Using Inducible Cre-LoxP Strategy. Methods in Molecular Biology, 2152, 253-258.

  5. Zhuang, T., Liu, J., Chen, X., Pi, J., Kuang, Y., Wang, Y., Tomlinson, B., Chan, P., Zhang, Q., Li, Y., Zheng, X., et al (2019). Cell-Specific Effects of GATA (GATA Zinc Finger Transcription Factor Family)-6 in Vascular Smooth Muscle and Endothelial Cells on Vascular Injury Neointimal Formation. Arteriosclerosis, Thrombosis, and Vascular Biology, 39(5), 888-901.

  6. Tang, X., Sullivan, K., Hong, C., Goddard, K., Mahadevan, A., Ren, A., Pardo, H., Peiper, A., Griffin, E., Tanes, C., Zheng, X., et al (2019). Distinct cellular roles for PDCD10 define a gut-brain axis in cerebral cavernous malformation. Science Translational Medicine, 11(520), 1-14.


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