Trent Woodruff

Dr Trent Woodruff is a Professor of Pharmacology at the University of Queensland, where he obtained a Ph.D. degree. Dr Woodruff’s research aims to develop new therapeutics for neurodegenerative diseases, and has a special emphasis on the innate immune system and role of neuroinflammation in those propagating diseases in the brain. A key focus of his current work is testing new drugs developed at the University of Queensland in models of motor neuron disease (amyotrophic lateral sclerosis), Huntington's disease, and Parkinson's disease, as well as maintaining an active interest in acute inflammatory disorders including sepsis and ischemia-reperfusion injuries. Using a series of potent and orally active complement C5a and NLRP3 inflammasome inhibitors developed at UQ, Prof Woodruff's team has demonstrated the therapeutic potential of targeting innate immune-mediated neuroinflammation to reduce neuronal cell death in animal models of these neurodegenerative diseases. His team has recently shown that in addition to their roles in neurodegeneration, innate immune factors also play essential roles in stem and neuronal cell development during embryogenesis, revealing the widespread physiological and pathological roles of this evolutionarily ancient immune system.

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University of Queensland

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Neuroinflammation 0 Innate Immune System 0 C5a Receptor 0 Neurodegenerative Diseases 0

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  1. Lo MW, Kemper C, Woodruff TM. COVID-19: Complement, Coagulation, and Collateral Damage [published online ahead of print, 2020 Jul 22]. J Immunol. 2020;ji2000644. doi:10.4049/jimmunol.2000644

  2. Li XX, Lee JD, Massey NL, et al. Pharmacological characterisation of small molecule C5aR1 inhibitors in human cells reveals biased activities for signalling and function [published online ahead of print, 2020 Jul 17]. Biochem Pharmacol. 2020;180:114156. doi:10.1016/j.bcp.2020.114156

  3. Lee JD, McDonald TS, Fung JNT, Woodruff TM. Absence of Receptor for Advanced Glycation End Product (RAGE) Reduces Inflammation and Extends Survival in the hSOD1G93AMouse Model of Amyotrophic Lateral Sclerosis [published online ahead of print, 2020 Jul 16]. Mol Neurobiol. 2020;10.1007/s12035-020-02019-9. doi:10.1007/s12035-020-02019-9

  4. Kumar V, Lee JD, Coulson EJ, Woodruff TM. A validated quantitative method for the assessment of neuroprotective barrier impairment in neurodegenerative disease models [published online ahead of print, 2020 Jul 6]. J Neurochem. 2020;10.1111/jnc.15119. doi:10.1111/jnc.15119

  5. Li XX, Clark RJ, Woodruff TM. C5aR2 Activation Broadly Modulates the Signaling and Function of Primary Human Macrophages. J Immunol. 2020;205(4):1102-1112. doi:10.4049/jimmunol.2000407

  6. Gordon R, Albornoz EA, Christie DC, et al. Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice. Sci Transl Med. 2018;10(465):eaah4066. doi:10.1126/scitranslmed.aah4066


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