Thomas Brunner

Dr Thomas Brunner became a full professor and chair in Biochemical Pharmacology since 2013, at the University of Konstanz, Germany. Dr. Brunner’s research pursues the understanding of molecular, biochemical and cell biological processes involved in immunopathological diseases and cancer development. In particular, Dr. Brunner’s team is interested in the role and regulation of apoptotic cell death in tumour cells, and in immune cells and tissue cells during inflammatory diseases. Meanwhile, they are also investigating the extra-adrenal synthesis of immunoregulatory glucocorticoids in the intestine, the skin and the lung, and how these glucocorticoids regulate the course of local inflammatory processes. Based on the research on apoptosis in the context of cancer cells, the Brunner group is interrogating the effect of thiazolides, which are antivirial drugs capable of inducing apoptosis, over the tumour cells, for instance colorectal tumour cells; they are working on the mechanisms of thiazolide-induced apoptosis in tumor cells and the therapeutic potential in cancer therapy.

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University of Konstanz

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Apoptotic Cell Death 0 Inflammatory Diseases and Cell Death 0 Apoptotic Pathways 0 Bcl-2 Interactome 0 Thiazolides Tumour Therapy 0 Glucocorticoids 0

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  1. Schwaderer J, Phan TS, Glöckner A, et al. Pharmacological LRH-1/Nr5a2 inhibition limits pro-inflammatory cytokine production in macrophages and associated experimental hepatitis. Cell Death Dis. 2020;11(2):154. Published 2020 Feb 28. doi:10.1038/s41419-020-2348-9

  2. Ripani P, Delp J, Bode K, Delgado M E, Dietrich L, Betzler V M, Yan N, von Scheven G, Mayer T U, Leist M, Brunner T.Thiazolides promote G1 cell cycle arrest in colorectal cancer cells by targeting the mitochondrial respiratory chain. Springer Nature. Oncogene. doi.org/10.1038/s41388-019-1142-6. December 2019

  3. Seitz C, Huang J, Geiselhöringer AL, Galbani-Bianchi P, Michalek S, Phan TS, Reinhold C, Dietrich L, Schmidt C, Corazza N, Delgado E, Schnalzger T, SchoonjansK, Brunner T. The orphan nuclear receptor LRH-1/NR5a2 critically regulates T cellfunctions. Sci Adv. 2019 Jul 17;5(7):eaav9732. doi: 10.1126/sciadv.aav9732.eCollection 2019 Jul. PubMed PMID: 31328159; PubMed Central PMCID: PMC6636985.

  4. Ahmed A, Schmidt C, Brunner T. Extra-Adrenal Glucocorticoid Synthesis in the

  5. Intestinal Mucosa: Between Immune Homeostasis and Immune Escape. Front Immunol. 2019 Jun 25;10:1438. doi: 10.3389/fimmu.2019.01438. eCollection 2019. Review. PubMed PMID: 31316505; PubMed Central PMCID: PMC6611402.

  6. Gougeon ML, Schwartz M, Brunner T, Ojcius DM. 130th anniversary of Institut

  7. Pasteur: celebrating science. Microbes Infect. 2019 Jun 25. pii:

  8. S1286-4579(19)30070-X. doi: 10.1016/j.micinf.2019.06.010. [Epub ahead of print] PubMed PMID: 31247327.


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