Shuo Huang

Professor Huang is leading his research group at State Key Laboratory of Analytical Chemistry for Life Sciences since 2015, right after he accomplished post-doctoral training at Newton University and doctoral study at Arizona State University. Dr. Shuo Huang's lab focuses on the fundamental study of single molecule biophysics and its corresponding applications as single molecule biosensors devices. The detailed research topics include: optical nanopore sequencing, single molecule medical diagnosis devices, nanopore based multi-modal optical platform.

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Nanjing University - Biomimetic Nanotechnology Lab

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DNA sequencing 1 Nanopore 1 Bionanotechnology 1


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  1. Wang, S.; Cao, J.; Jia, W.; Guo, W.; Yan, S.; Wang, Y.; Zhang, P.; Chen, H.-Y. *; Huang, S.*, Single molecule observation of hard–soft-acid–base (HSAB) interaction in engineered Mycobacterium smegmatis porin A (MspA) nanopores. Chemical Science 2020. DOI: 10.1039/C9SC05260G

  2. Cao, J.; Jia, W.; Zhang, J.; Xu, X.; Yan, S.; Wang, Y.; Zhang, P.; Chen, H.-Y.; Huang, S.*, Giant single molecule chemistry events observed from a tetrachloroaurate(III) embedded Mycobacterium smegmatis porin A nanopore. Nature Communications 2019, 10 (1), 5668.

  3. Wang, Y. Q.; Wang, Y.; Du, X. Y.; Yan, S. H.; Zhang, P. K.; Chen, H. Y.*; Huang, S.*, Electrode-free nanopore sensing by DiffusiOptoPhysiology. Science Advances 2019, 5.

  4. Wang, Y.#; Patil, K. M.#; Yan, S. H.; Zhang, P. K.; Guo, W. M.; Wang, Y. Q.; Chen, H. Y.; Gillingham, D.*; Huang, S.*, Nanopore Sequencing Accurately Identifies the Mutagenic DNA Lesion O6-Carboxymethyl Guanine and Reveals Its Behavior in Replication. Angewandte Chemie International Edition 2019, 58 (25), 8432-8436. ( #These authors contribute equally) 

  5. Yan, S. H. #; Li, X. T. #*; Zhang, P. K.; Wang, Y. Q.; Chen, H. Y.; Huang, S.*; Yu, H. Y.*, Direct sequencing of 2′-deoxy-2′-fluoroarabinonucleic acid (FANA) using nanopore-induced phase-shift sequencing (NIPSS). Chemical Science 2019, 10 (10), 3110-3117. ( #These authors contribute equally)

  6. Wang, Y. Q.; Yan, S. H.; Zhang, P. K.; Zeng, Z. D.; Zhao, D.; Wang, J. X.; Chen, H. Y.*; Huang, S.*, Osmosis-Driven Motion-Type Modulation of Biological Nanopores for Parallel Optical Nucleic Acid Sensing. ACS Applied Materials & Interfaces 2018, 10 (9), 7788-7797.

  7. Huang, S.#; Romero-Ruiz, M.#; Castell, O. K.; Bayley, H.; Wallace, M. I.*, High-throughput optical sensing of nucleic acids in a nanopore array. Nature Nanotechnology 2015, 10, 986. ( #These authors contribute equally)

  8. Huang, S.; He, J.; Chang, S.; Zhang, P. M.; Liang, F.; Li, S. Q.; Tuchband, M.; Fuhrmann, A.; Ros, R.; Lindsay, S.*, Identifying single bases in a DNA oligomer with electron tunnelling. Nature Nanotechnology 2010, 5 (12), 868-873.

  9. Huang, S.; Chang, S.; He, J.; Zhang, P. M.; Liang, F.; Tuchband, M.; Li, S. Q.; Lindsay, S.*, Recognition Tunneling Measurement of the Conductance of DNA Bases Embedded in Self-Assembled Monolayers. The Journal of Physical Chemistry C 2010, 114 (48), 20443-20448.

  10. Huang, S.*, Nanopore-based sensing devices and applications to genome sequencing: a brief history and the missing pieces. Chinese science bulletin 2014, 59 (35), 4918-4928.

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