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DNA sequencing 1 Nanopore 1 Bionanotechnology 1
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This is the first episode of MolecularCloud Pioneer Scientist interview series. In this interview, MolecularCloud talks with Prof. Shuo Huang from Nanjing University about the recent publications of Dr. Huang’s team and the future prospect of biological nanopore technology. The ...Learn More
The increasing number of confirmed COVID-19 cases is prompting an unprecedented global effort to find a treatment for the disease. Given the fact that a new drug development could be a decade work from initial discovery to the marketplace, scientists are racing to search a cure ...Learn More
The previous article on precision medicine was focused on Pharmacogenomics as a fundamental aspect of cancer therapeutics. In this sequel, emphasis would be on the role of immuno-oncology in personalization of cancer therapy, citing anti PD therapy as an example with hypothetical ...Learn More
IntroductionA gleam of light finally shone down on the global crisis of the prolonged battle against COVID-19, giving people hopes of preventive care and treatment in the near future by monoclonal antibodies against SARS-CoV-2. As stated the news of NIH’s phase III clinical ...Learn More
"Those who do not know history are obliged to repeat it" This famous phrase that could be from any history teacher to his suspended students has been attributed to great figures in history such as Napoleon or the philosopher George Santayana. In a modern version of it we could say ...Learn More
In recent years there is an increasing number of cytotoxic chemotherapeutic compounds with the ability to rapidly kill dividing cancer cells in preference to non-dividing healthy cells. Nevertheless, the major drawback of chemotherapy is that, in addition to damaging the cancer ...Learn More
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Wang, S.; Cao, J.; Jia, W.; Guo, W.; Yan, S.; Wang, Y.; Zhang, P.; Chen, H.-Y. *; Huang, S.*, Single molecule observation of hard–soft-acid–base (HSAB) interaction in engineered Mycobacterium smegmatis porin A (MspA) nanopores. Chemical Science 2020. DOI: 10.1039/C9SC05260G
Cao, J.; Jia, W.; Zhang, J.; Xu, X.; Yan, S.; Wang, Y.; Zhang, P.; Chen, H.-Y.; Huang, S.*, Giant single molecule chemistry events observed from a tetrachloroaurate(III) embedded Mycobacterium smegmatis porin A nanopore. Nature Communications 2019, 10 (1), 5668.
Wang, Y. Q.; Wang, Y.; Du, X. Y.; Yan, S. H.; Zhang, P. K.; Chen, H. Y.*; Huang, S.*, Electrode-free nanopore sensing by DiffusiOptoPhysiology. Science Advances 2019, 5.
Wang, Y.#; Patil, K. M.#; Yan, S. H.; Zhang, P. K.; Guo, W. M.; Wang, Y. Q.; Chen, H. Y.; Gillingham, D.*; Huang, S.*, Nanopore Sequencing Accurately Identifies the Mutagenic DNA Lesion O6-Carboxymethyl Guanine and Reveals Its Behavior in Replication. Angewandte Chemie International Edition 2019, 58 (25), 8432-8436. ( #These authors contribute equally)
Yan, S. H. #; Li, X. T. #*; Zhang, P. K.; Wang, Y. Q.; Chen, H. Y.; Huang, S.*; Yu, H. Y.*, Direct sequencing of 2′-deoxy-2′-fluoroarabinonucleic acid (FANA) using nanopore-induced phase-shift sequencing (NIPSS). Chemical Science 2019, 10 (10), 3110-3117. ( #These authors contribute equally)
Wang, Y. Q.; Yan, S. H.; Zhang, P. K.; Zeng, Z. D.; Zhao, D.; Wang, J. X.; Chen, H. Y.*; Huang, S.*, Osmosis-Driven Motion-Type Modulation of Biological Nanopores for Parallel Optical Nucleic Acid Sensing. ACS Applied Materials & Interfaces 2018, 10 (9), 7788-7797.
Huang, S.#; Romero-Ruiz, M.#; Castell, O. K.; Bayley, H.; Wallace, M. I.*, High-throughput optical sensing of nucleic acids in a nanopore array. Nature Nanotechnology 2015, 10, 986. ( #These authors contribute equally)
Huang, S.; He, J.; Chang, S.; Zhang, P. M.; Liang, F.; Li, S. Q.; Tuchband, M.; Fuhrmann, A.; Ros, R.; Lindsay, S.*, Identifying single bases in a DNA oligomer with electron tunnelling. Nature Nanotechnology 2010, 5 (12), 868-873.
Huang, S.; Chang, S.; He, J.; Zhang, P. M.; Liang, F.; Tuchband, M.; Li, S. Q.; Lindsay, S.*, Recognition Tunneling Measurement of the Conductance of DNA Bases Embedded in Self-Assembled Monolayers. The Journal of Physical Chemistry C 2010, 114 (48), 20443-20448.
Huang, S.*, Nanopore-based sensing devices and applications to genome sequencing: a brief history and the missing pieces. Chinese science bulletin 2014, 59 (35), 4918-4928.
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