Philippe Cluzel

Dr. Philippe Cluzel is Professor of Molecular and Cellular Biology and Gordon Mckay Professor of Applied Physics at Harvard University. As a Principal Investigator, he is leading lab research which focuses on real-time systems analysis of signal transduction and genetic networks at the single cell level. Recent projects of the lab involve the investigation of the temporal dynamics of the flagellum assembly cascade in E. coli at single-cell level, meanwhile, the lab also looks into the degeneracy pattern in the genetic code under environmental influences and multi-drug resistance in microbes and cancer cells. The Cluzel Lab developed a microfluidic platform for high-throughput measurement of growth and gene expression in single, living bacterial cells in 2012.

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Harvard University

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System Biology 0 Bioinformatics 0 Real-time Single-cell Analysis 0 Statistical Analysis of Biological Systems 0 Genetic Code Degeneracy 0

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  1. Kim JM, Garcia-Alcala M, Balleza E, Cluzel P. Stochastic transcriptional pulses orchestrate flagellar biosynthesis in Escherichia coli. Sci Adv. 2020;6(6):eaax0947. Published 2020 Feb 5. doi:10.1126/sciadv.aax0947

  2. Balleza E, Kim JM, Cluzel P. Systematic characterization of maturation time of fluorescent proteins in living cells. Nat Methods. 2018;15(1):47-51. doi:10.1038/nmeth.4509

  3. Wood KB, Wood KC, Nishida S, Cluzel P. Uncovering scaling laws to infer multidrug response of resistant microbes and cancer cells. Cell Rep. 2014;6(6):1073-1084. doi:10.1016/j.celrep.2014.02.007

  4. Subramaniam AR, Pan T, Cluzel P. Environmental perturbations lift the degeneracy of the genetic code to regulate protein levels in bacteria. Proc Natl Acad Sci U S A. 2013;110(6):2419-2424. doi:10.1073/pnas.1211077110

  5. Moffitt JR, Lee JB, Cluzel P. The single-cell chemostat: an agarose-based, microfluidic device for high-throughput, single-cell studies of bacteria and bacterial communities. Lab Chip. 2012;12(8):1487-1494. doi:10.1039/c2lc00009a


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