Peter Penzes

Dr. Penzes is a professor of Physiology, Pharmacology and Psychiatry and Behavioral Sciences at Northwestern University. Dr. Penzes Lab aims to uncover the molecular and cellular mechanisms whereby neurons communicate with each other within brain circuits, how they malfunction in neuropsychiatric disorders, and to use this knowledge to develop new therapies for such disorders. They employ a multi-disciplinary and multi-level combination of methodologies including super-resolution-, multi-photon-, calcium-, and time-lapse imaging, mouse genetics and behavioral analysis, human iPSC-derived neurons, bioinformatics, neuroproteomics, high-throughput and high content screens.

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Northwestern University

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Neuropsychiatric disorders 0 Mouse genetics 0

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  1. Zaccard, Colleen R., et al. "Rapid 3D Enhanced Resolution Microscopy Reveals Diversity in Dendritic Spinule Dynamics, Regulation, and Function." Neuron (2020).

  2. Culotta, Lorenza, and Peter Penzes. "Exploring the mechanisms underlying excitation/inhibition imbalance in human iPSC-derived models of ASD." Molecular Autism 11.1 (2020): 1-11.

  3. Yoon, Sehyoun, et al. "Usp9X controls Ankyrin-repeat domain protein homeostasis during dendritic spine development." Neuron 105.3 (2020): 506-521.

  4. Yoon, Sehyoun, Euan Parnell, and Peter Penzes. "TGF-β-Induced Phosphorylation of Usp9X Stabilizes Ankyrin-G and Regulates Dendritic Spine Development and Maintenance." Cell Reports 31.8 (2020): 107685.


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