Omar Abudayyeh

Dr. Omar Abudayyeh conducted his PhD work in Feng Zhang’s lab at the McGovern Institute and Broad Institute of MIT and Harvard. He is one of the first members of the McGovern Institute Fellows program, which supports the transition to independent research for exceptional recent PhD graduates. Omar Abudayyeh works on novel genome editing and gene delivery tools, and applying these tools towards the study of aging. While CRISPR is perhaps best known as a DNA editing tool, Abudayyeh’s team has discovered new CRISPR enzymes, such as the RNA-targeting CRISPR-Cas13, and adapted these enzymes for novel technologies, such as a simple and inexpensive tool to detect human diseases. This technology, called SHERLOCK, can be applied to detect viruses, bacteria – even genetic signatures associated with cancer – in virtually any location. Abudayyeh and McGovern Fellow Jonathan Gootenberg continue to mine bacterial systems for new technologies to better enable gene therapy as well as applying these technologies towards studying mechanisms of aging. Using next-generation single-cell sequencing and novel tools for perturbing cell states, Dr. Abudayyeh is determining, with unprecedented resolution, the cell types that arise in the aging brain and how mechanisms, such as senescence, drive detrimental processes in tissues. The ultimate goal is to use this information for building a detailed roadmap of aging circuits and to eventually reverse states of aging for regenerating tissues like the brain.

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MIT McGovern Institute

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novel genome editing 0 gene delivery tools 0 aging 0 next-generation single-cell sequencing 0

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  1. Joung, J., Ladha, A., Saito, M., Segel, M., Bruneau, R., Huang, M. L. W., ... & Greninger, A. L. (2020). Point-of-care testing for COVID-19 using SHERLOCK diagnostics. medRxiv.

  2. Konermann, S., Brigham, M. D., Trevino, A. E., Joung, J., Abudayyeh, O. O., Barcena, C., ... & Nureki, O. (2015). Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex. Nature, 517(7536), 583-588.

  3. Abudayyeh, O. O., Gootenberg, J. S., Essletzbichler, P., Han, S., Joung, J., Belanto, J. J., ... & Lander, E. S. (2017). RNA targeting with CRISPR–Cas13. Nature, 550(7675), 280-284.

  4. Gootenberg, J. S., Abudayyeh, O. O., Lee, J. W., Essletzbichler, P., Dy, A. J., Joung, J., ... & Myhrvold, C. (2017). Nucleic acid detection with CRISPR-Cas13a/C2c2. Science, 356(6336), 438-442.

  5. Abudayyeh, O. O., Gootenberg, J. S., Konermann, S., Joung, J., Slaymaker, I. M., Cox, D. B., ... & Severinov, K. (2016). C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector. Science, 353(6299).


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