Olivier Gires

Oliver Gires is the Head of the ENT research at Ludwig-Maximilians-University Munich. Dr Gires and his group’s research concentrate on the molecular signals emitted by tumour cells – the tumour-associated antigens (TAAs) which are proteins produced in immune response, and circulating tumour DNA released when broken down, known as ctDNAs. The team wants to develop the potential of those molecules as diagnostic and prognostic markers, as well as the availability of TAAs such as EpCAM as therapeutic targets, through molecular biological and clinical translational characterization of which. Knowledge of the expression, availability and function of TAAs in the development and progression of tumours and in metastasis is considered as an essential prerequisite for the development of new therapeutic agents for the treatment of carcinomas. The group is developing ctDNA as a "liquid biopsy" in ENT carcinoma patients; recently, the Gires Lab successfully shown that copy number instability index (CNI), which measures the genetic instability and the amount of ctDNA, is suitable as a prognostic marker for survival and as a prognostic value for lymphogenic metastasis.

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Ludwig-Maximilians University of Munich

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Tumour-Associated Antigens (TAAs) 0 Circulating Tumour DNAs (ctDNAs) 0 ENT Carcinoma 0 Molecular Oncology 0 EpCAM 0

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  1. Gires O, Pan M, Schinke H, Canis M, Baeuerle PA. Expression and function of epithelial cell adhesion molecule EpCAM: where are we after 40 years? [published online ahead of print, 2020 Jun 7]. Cancer Metastasis Rev. 2020;10.1007/s10555-020-09898-3. doi:10.1007/s10555-020-09898-3

  2. Simon F, Schwenk-Zieger S, Becker S, Unger K, Gires O, Baumeister P. Cigarette Smoke Reduces the Efficacy of Cisplatin in Head and Neck Cancer Cells - Role of ABCG2. Anticancer Res. 2020;40(3):1277-1284. doi:10.21873/anticanres.14069

  3. Zhu R, Gires O, Zhu L, et al. TSPAN8 promotes cancer cell stemness via activation of sonic Hedgehog signaling. Nat Commun. 2019;10(1):2863. Published 2019 Jun 28. doi:10.1038/s41467-019-10739-3

  4. Liu X, Li J, Cadilha BL, et al. Epithelial-type systemic breast carcinoma cells with a restricted mesenchymal transition are a major source of metastasis. Sci Adv. 2019;5(6):eaav4275. Published 2019 Jun 19. doi:10.1126/sciadv.aav4275

  5. Baumeister P, Hollmann A, Kitz J, et al. High Expression of EpCAM and Sox2 is a Positive Prognosticator of Clinical Outcome for Head and Neck Carcinoma. Sci Rep. 2018;8(1):14582. Published 2018 Oct 1. doi:10.1038/s41598-018-32178-8


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