Noor Gammoh

Noor Gammoh completed her PhD at the laboratory of Dr. Lawrence Banks in Italy, before she received postdoctoral training at to the Memorial Sloan Kettering Cancer Centre in New York in 2009. There, she shifted the focus of research from the investigation of the role of Human Papillomavirus-encoded proteins during oncogenesis to the molecular biology of autophagy and its role during cell death and tumorigenesis. Now, as a Chancellor’s fellow at the University of Edinburgh since 2013, Noor continues to embark the research on autophagy and its relevance in the models of aggressive cancers, especially glioblastoma multiforme (GBM), with her lab group. The current research of Noor’s lab emphasizes three topics, which are respectively the understanding of how autophagy affects aggressive cancers like GBM, the molecular mechanisms of autophagy-reated protein (ATG), which is a key factor for the formation of the autophagosome, and the identification of important cellular regulators as potential drug targets for the inhibition of autophagy. Overall, Noor and her lab aim to improve current treatment for GBM based on the knowledge of autophagy pathways.

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Molecular mechanisms of autophagy 0 ATG proteins 0 glioblastoma multiforme (GBM) 0

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  1. Martello A, Lauriola A, Mellis D, Parish E, Dawson JC, Imrie L et al. Trichoplein binds PCM1 and controls endothelial cell function by regulating autophagy. EMBO Reports. 2020 Apr 26.

  2. Dudley LJ, Makar AN, Gammoh N. Membrane targeting of core autophagy players during autophagosome biogenesis: Running Title : Recruitment of ATG proteins to the phagophore. Febs Journal. 2020 Apr 17.

  3. Fraser J, Simpson J, Fontana R, Kishi-Itakura C, Ktistakis NT, Gammoh N. Targeting of Early Endosomes by Autophagy Facilitates EGFR Recycling and Signalling. EMBO Reports. 2019 Aug 26.

  4. Dudley L, Gonzalez Cabodevilla A, Makar A, Sztacho M, Michelberger T, Marsh JA et al. Intrinsic lipid binding activity of ATG16L1 supports efficient membrane anchoring and autophagy. EMBO Journal. 2019 May 2;38(9).

  5. Fletcher K, Ulferts R, Jacquin E, Veith T, Gammoh N, Arasteh JM et al. The WD40 domain of ATG16L1 is required for its non-canonical role in lipidation of LC3 at single membranes. EMBO Journal. 2018 Jan 9.


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