Nico Dissmyer

Prof. Nico Dissmyer obtained his PhD in Biochemistry and Biophysics for his work on Cyclin-Dependent-Kinase A;1 and other cell regulators from the Universität zu Köln in 2009, while he finished his postdoc at the Institut de Biologie Moléculaire des Plantes of the CNRS at Strasbourg. Before receiving his professorship of plant physiology at the University of Osnabrück in July 2018, Prof. Dissmyer has been leading a junior research group at the Leibniz Institute of Plant Biochemistry (IPB) and ScienceCampus Halle since 2011; the group moved to the University of Osnabrück in 2019. The current research focus of Nico’s lab encompasses the biological relevance and molecular function of a highly specialized protein modification pathway called the N-end rule pathway or the N-degron pathway. The N-degron pathway is part of the Ubiquitin proteasome system and can lead to rapid degradation of target proteins from the living cell and by this abolishing the same time. The pathway reveals its vital function in protein quality control, protein homeostasis, and general development universally among organisms; Prof. Dissmyer suggests the pharmaceutical potential of the N-degron pathway, as the degradation tag can be modified to achieve an either increased or reduced turnover of the substrates.

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University of Osnabrück, Dissmyer Lab

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Plant Physiology 0 N-degron pathway 0 the N-end rule pathway 0 Ubiquitination 0

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  1. Goslin K, Eschen-Lippold L, Naumann C, et al. Differential N-end Rule Degradation of RIN4/NOI Fragments Generated by the AvrRpt2 Effector Protease [published correction appears in Plant Physiol. 2019 Nov;181(3):1389-1391]. Plant Physiol. 2019;180(4):2272-2289. doi:10.1104/pp.19.00251

  2. Dissmeyer N. Conditional Protein Function via N-Degron Pathway-Mediated Proteostasis in Stress Physiology. Annu Rev Plant Biol. 2019;70:83-117. doi:10.1146/annurev-arplant-050718-095937

  3. Vicente J, Mendiondo GM, Pauwels J, et al. Distinct branches of the N-end rule pathway modulate the plant immune response. New Phytol. 2019;221(2):988-1000. doi:10.1111/nph.15387

  4. Wijnker E, Harashima H, Müller K, et al. The Cdk1/Cdk2 homolog CDKA;1 controls the recombination landscape in Arabidopsis. Proc Natl Acad Sci U S A. 2019;116(25):12534-12539. doi:10.1073/pnas.1820753116

  5. Dissmeyer N, Rivas S, Graciet E. Life and death of proteins after protease cleavage: protein degradation by the N-end rule pathway. New Phytol. 2018;218(3):929-935. doi:10.1111/nph.14619


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