Navdar Sever
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Navdar Sever-Harvard Medical School
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Biochemistry 0 Genetics 0 Molecular Biology 0 Cell Biology 0
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Neutralizing antibodies (NAbs) are critical human immune defense mechanisms against viral infections. NAbs can bind to sites on the virus and inhibit entry of that virus into the host. It is a key parameter to evaluate COVID-19 vaccine efficacy per Guidelines from Development and ...Learn More
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This 3D animation shows you how DNA is copied in a cell. It shows how both strands of the DNA helix are unzipped and copied to produce two identical DNA molecules. TranscriptDNA is a molecule made up of two strands twisted around each other in a double helix shape. Each strand is ...Learn More
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"Those who do not know history are obliged to repeat it" This famous phrase that could be from any history teacher to his suspended students has been attributed to great figures in history such as Napoleon or the philosopher George Santayana. In a modern version of it we could say ...Learn More
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Sever N, Mann RK, Xu L, Snell WJ, Hernandez-Lara CI, Porter NA, Beachy PA (2016) A novel mode of Smoothened inhibition by endogenous B-ring oxysterols in Hedgehog signaling. Proc Natl Acad Sci USA (published ahead of print May 9, 2016)
Strating JR, van der Linden L, Albulescu L, Bigay J, Arita M, Delang L, Leyssen P, van der Schaar HM, Lanke KH, Thibaut HJ, Ulferts R, Drin G, Schlinck N, Wubbolts RW, Sever N, Head SA, Liu JO, Beachy PA, De Matteis MA, Shair MD, Olkkonen VM, Neyts J, van Kuppeveld FJ. (2015) Itraconazole inhibits enterovirus replication by targeting the oxysterol-binding protein. Cell Rep 10, 600-15.
Kim J, Hsia EY, Kim J, Sever N, Beachy PA, Zheng X. (2014) Simultaneous measurement of Smoothened entry into and exit from the primary cilium. PLoS One 9:e104070.
Myers BR, Sever N, Chong YC, Kim J, Belani JD, Rychnovsky S, Bazan JF, Beachy PA. (2013) Hedgehog pathway modulation by multiple lipid binding sites on the Smoothened effector of signal response. Dev Cell 26, 346-57.
Zheng X, Mann RK, Sever N, Beachy PA. (2010) Genetic and biochemical definition of the Hedgehog receptor. Genes Dev 24, 57-71.
Dwyer JR, Sever N, Carlson M, Nelson SF, Beachy PA, Parhami F. (2007) Oxysterols are novel activators of the Hedgehog signaling pathway in pluripotent mesenchymal cells. J Biol Chem 282, 8959-68.
Song BL, Sever N, DeBose-Boyd RA. (2005) Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase. Mol Cell 19, 829-40.
Lee PC, Sever N, DeBose-Boyd RA. (2005) Isolation of sterol-resistant Chinese hamster ovary cells with genetic deficiencies in both Insig-1 and Insig-2. J Biol Chem 280, 25242-9.
Sever N, Lee PC, Song BL, Rawson RB, DeBose-Boyd RA. (2004) Isolation of cells lacking Insig-1 through selection with SR-12813, an agent that stimulates degradation of 3-hydroxy-3-methylglutaryl coenzyme A reductase. J Biol Chem 279, 43136-47.
Sever N, Song BL, Yabe D, Goldstein JL, Brown MS, DeBose-Boyd RA. (2003) Insig-dependent ubiquitination and degradation of mammalian 3-hydroxy-3-methylglutaryl CoA reductase stimulated by sterols and geranylgeraniol. J Biol Chem 278, 52479-90.
Sever N, Yang T, Brown MS, Goldstein JL, DeBose-Boyd RA. (2003) Accelerated degradation of HMG CoA reductase mediated by binding of insig-1 to its sterol-sensing domain. Mol Cell 11, 25-33.
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