Moorthy Palanimuthu Ponnusamy

Dr. Moorthy Palanimuthu Ponnusamy received his doctoral degree in 2005 from the Madras University. He is currently a Associate Professor of Biochemistry and Molecular Biology at the University of Nebraska Medical center. His research is focused on identification and characterization of cancer stem cell populations in pancreatic and ovarian cancers. Over the last several years, it has been evident that a small population (less than 5%) of cancer cells, referred as cancer stem cells is responsible for the disease aggressiveness, resistance to therapy and spread of the tumor. Cancer stem cells are difficult to target using conventional therapies because they are drug resistant. They have recently identified a novel biomarker, pancreatic differentiation 2 (PD2) that is involved in the maintenance of drug-resistance and self-renewal of cancer stem cells. Their current research is focused on investigating the impact of PD2 in the self-renewal and drug-resistance of cancer stem cells. The identification of biomarker for the maintenance of cancer stem cells would provide critical information for the long-term goal of developing novel targeted therapy against pancreatic and ovarian cancer.

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University of Nebraska Medical center

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Characterization of cancer stem cells 0 Mechanism of Metastasis and Tumor Glycobiology 0 Biochemistry 0 Molecular Biology 0

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  1. Moorthy PP, Kumar AA, Devaraj H. Expression of the Gas7 gene and Oct4 in embryonic stem cells of mice. Stem Cells Dev. 2005 Dec;14(6):664-70. doi: 10.1089/scd.2005.14.664. PubMed PMID: 16433621.

  2. Ponnusamy MP, Venkatraman G, Singh AP, Chauhan SC, Johansson SL, Jain M, Smith L, Davis JS, Remmenga SW, Batra SK. Expression of TAG-72 in ovarian cancer and its correlation with tumor stage and patient prognosis. Cancer Lett. 2007 Jun 28;251(2):247-57. doi: 10.1016/j.canlet.2006.11.025. Epub 2007 Jan 8. PubMed PMID: 17210225.

  3. Andrianifahanana M, Singh AP, Nemos C, Ponnusamy MP, Moniaux N, Mehta PP, Varshney GC, Batra SK. IFN-gamma-induced expression of MUC4 in pancreatic cancer cells is mediated by STAT-1 upregulation: a novel mechanism for IFN-gamma response. Oncogene. 2007 Nov 8;26(51):7251-61. doi: 10.1038/sj.onc.1210532. Epub 2007 May 21. PubMed PMID: 17525742.

  4. Ponnusamy MP, Singh AP, Jain M, Chakraborty S, Moniaux N, Batra SK. MUC4 activates HER2 signalling and enhances the motility of human ovarian cancer cells. Br J Cancer. 2008 Aug 5;99(3):520-6. doi: 10.1038/sj.bjc.6604517. PubMed PMID: 18665193; PubMed Central PMCID: PMC2527793.

  5. Deb S, Ponnusamy MP, Senapati S, Dey P, Batra SK. Human PAF complexes in endocrine tumors and pancreatic cancer. Expert Rev Endocrinol Metab. 2008 Sep;3(5):557-565. doi: 10.1586/17446651.3.5.557. PubMed PMID: 30290411.

  6. Ponnusamy MP, Batra SK. Ovarian cancer: emerging concept on cancer stem cells. J Ovarian Res. 2008 Oct 12;1(1):4. doi: 10.1186/1757-2215-1-4. PubMed PMID: 19014671; PubMed Central PMCID: PMC2584054.

  7. Singh AP, Senapati S, Ponnusamy MP, Jain M, Lele SM, Davis JS, Remmenga S, Batra SK. Clinical potential of mucins in diagnosis, prognosis, and therapy of ovarian cancer. Lancet Oncol. 2008 Nov;9(11):1076-85. doi: 10.1016/S1470-2045(08)70277-8. Review. PubMed PMID: 19012856; PubMed Central PMCID: PMC5600479.

  8. Torres MP, Ponnusamy MP, Lakshmanan I, Batra SK. Immunopathogenesis of ovarian cancer. Minerva Med. 2009 Oct;100(5):385-400. Review. PubMed PMID: 19910891.

  9. Ponnusamy MP, Deb S, Dey P, Chakraborty S, Rachagani S, Senapati S, Batra SK. RNA polymerase II associated factor 1/PD2 maintains self-renewal by its interaction with Oct3/4 in mouse embryonic stem cells. Stem Cells. 2009 Dec;27(12):3001-11. doi: 10.1002/stem.237. PubMed PMID: 19821493; PubMed Central PMCID: PMC2891238.

  10. Torres MP, Ponnusamy MP, Chakraborty S, Smith LM, Das S, Arafat HA, Batra SK. Effects of thymoquinone in the expression of mucin 4 in pancreatic cancer cells: implications for the development of novel cancer therapies. Mol Cancer Ther. 2010 May;9(5):1419-31. doi: 10.1158/1535-7163.MCT-10-0075. Epub 2010 Apr 27. PubMed PMID: 20423995; PubMed Central PMCID: PMC2906253.

  11. Ponnusamy MP, Lakshmanan I, Jain M, Das S, Chakraborty S, Dey P, Batra SK. MUC4 mucin-induced epithelial to mesenchymal transition: a novel mechanism for metastasis of human ovarian cancer cells. Oncogene. 2010 Oct 21;29(42):5741-54. doi: 10.1038/onc.2010.309. Epub 2010 Aug 9. PubMed PMID: 20697346; PubMed Central PMCID: PMC3005772.

  12. Ponnusamy. Stem Cell Research and Cancer Stem Cells. J. Tissue Sci. Eng. 2011;

  13. Rachagani S, Senapati S, Chakraborty S, Ponnusamy MP, Kumar S, Smith LM, Jain M, Batra SK. Activated KrasG¹²D is associated with invasion and metastasis of pancreatic cancer cells through inhibition of E-cadherin. Br J Cancer. 2011 Mar 15;104(6):1038-48. doi: 10.1038/bjc.2011.31. Epub 2011 Mar 1. PubMed PMID: 21364589; PubMed Central PMCID: PMC3065271.

  14. Mukhopadhyay P, Chakraborty S, Ponnusamy MP, Lakshmanan I, Jain M, Batra SK. Mucins in the pathogenesis of breast cancer: implications in diagnosis, prognosis and therapy. Biochim Biophys Acta. 2011 Apr;1815(2):224-40. doi: 10.1016/j.bbcan.2011.01.001. Epub 2011 Jan 26. Review. PubMed PMID: 21277939; PubMed Central PMCID: PMC3230300.

  15. Ponnusamy MP, Seshacharyulu P, Vaz A, Dey P, Batra SK. MUC4 stabilizes HER2 expression and maintains the cancer stem cell population in ovarian cancer cells. J Ovarian Res. 2011 Apr 26;4(1):7. doi: 10.1186/1757-2215-4-7. PubMed PMID: 21521521; PubMed Central PMCID: PMC3111401.

  16. Dey P, Ponnusamy MP, Deb S, Batra SK. Human RNA polymerase II-association factor 1 (hPaf1/PD2) regulates histone methylation and chromatin remodeling in pancreatic cancer. PLoS One. 2011;6(10):e26926. doi: 10.1371/journal.pone.0026926. Epub 2011 Oct 27. PubMed PMID: 22046413; PubMed Central PMCID: PMC3203178.

  17. Haridas D, Chakraborty S, Ponnusamy MP, Lakshmanan I, Rachagani S, Cruz E, Kumar S, Das S, Lele SM, Anderson JM, Wittel UA, Hollingsworth MA, Batra SK. Pathobiological implications of MUC16 expression in pancreatic cancer. PLoS One. 2011;6(10):e26839. doi: 10.1371/journal.pone.0026839. Epub 2011 Oct 31. PubMed PMID: 22066010; PubMed Central PMCID: PMC3204976.

  18. Seshacharyulu P, Ponnusamy MP, Haridas D, Jain M, Ganti AK, Batra SK. Targeting the EGFR signaling pathway in cancer therapy. Expert Opin Ther Targets. 2012 Jan;16(1):15-31. doi: 10.1517/14728222.2011.648617. Epub 2012 Jan 12. Review. PubMed PMID: 22239438; PubMed Central PMCID: PMC3291787.

  19. Lakshmanan I, Ponnusamy MP, Das S, Chakraborty S, Haridas D, Mukhopadhyay P, Lele SM, Batra SK. MUC16 induced rapid G2/M transition via interactions with JAK2 for increased proliferation and anti-apoptosis in breast cancer cells. Oncogene. 2012 Feb 16;31(7):805-17. doi: 10.1038/onc.2011.297. Epub 2011 Jul 25. PubMed PMID: 21785467; PubMed Central PMCID: PMC3288594.

  20. Kunigal S, Ponnusamy MP, Momi N, Batra SK, Chellappan SP. Nicotine, IFN-γ and retinoic acid mediated induction of MUC4 in pancreatic cancer requires E2F1 and STAT-1 transcription factors and utilize different signaling cascades. Mol Cancer. 2012 Apr 26;11:24. doi: 10.1186/1476-4598-11-24. PubMed PMID: 22537161; PubMed Central PMCID: PMC3464875.

  21. Momi N, Kaur S, Ponnusamy MP, Kumar S, Wittel UA, Batra SK. Interplay between smoking-induced genotoxicity and altered signaling in pancreatic carcinogenesis. Carcinogenesis. 2012 Sep;33(9):1617-28. doi: 10.1093/carcin/bgs186. Epub 2012 May 23. Review. PubMed PMID: 22623649; PubMed Central PMCID: PMC3514894.

  22. Rachagani S, Macha MA, Ponnusamy MP, Haridas D, Kaur S, Jain M, Batra SK. MUC4 potentiates invasion and metastasis of pancreatic cancer cells through stabilization of fibroblast growth factor receptor 1. Carcinogenesis. 2012 Oct;33(10):1953-64. doi: 10.1093/carcin/bgs225. Epub 2012 Jul 12. PubMed PMID: 22791819; PubMed Central PMCID: PMC3529557.

  23. Rachagani S, Torres MP, Kumar S, Haridas D, Baine M, Macha MA, Kaur S, Ponnusamy MP, Dey P, Seshacharyulu P, Johansson SL, Jain M, Wagner KU, Batra SK. Mucin (Muc) expression during pancreatic cancer progression in spontaneous mouse model: potential implications for diagnosis and therapy. J Hematol Oncol. 2012 Oct 26;5:68. doi: 10.1186/1756-8722-5-68. PubMed PMID: 23102107; PubMed Central PMCID: PMC3511181.

  24. Mukhopadhyay P, Lakshmanan I, Ponnusamy MP, Chakraborty S, Jain M, Pai P, Smith LM, Lele SM, Batra SK. MUC4 overexpression augments cell migration and metastasis through EGFR family proteins in triple negative breast cancer cells. PLoS One. 2013;8(2):e54455. doi: 10.1371/journal.pone.0054455. Epub 2013 Feb 11. PubMed PMID: 23408941; PubMed Central PMCID: PMC3569463.

  25. Momi N, Ponnusamy MP, Kaur S, Rachagani S, Kunigal SS, Chellappan S, Ouellette MM, Batra SK. Nicotine/cigarette smoke promotes metastasis of pancreatic cancer through α7nAChR-mediated MUC4 upregulation. Oncogene. 2013 Mar 14;32(11):1384-95. doi: 10.1038/onc.2012.163. Epub 2012 May 21. PubMed PMID: 22614008; PubMed Central PMCID: PMC3427417.

  26. Vaz AP, Ponnusamy MP, Batra SK. Cancer stem cells and therapeutic targets: an emerging field for cancer treatment. Drug Deliv Transl Res. 2013 Apr;3(2):113-20. doi: 10.1007/s13346-012-0095-x. PubMed PMID: 24077517; PubMed Central PMCID: PMC3784304.

  27. Majhi PD, Lakshmanan I, Ponnusamy MP, Jain M, Das S, Kaur S, Shimizu ST, West WW, Johansson SL, Smith LM, Yu F, Rolle CE, Sharma P, Carey GB, Batra SK, Ganti AK. Pathobiological implications of MUC4 in non-small-cell lung cancer. J Thorac Oncol. 2013 Apr;8(4):398-407. doi: 10.1097/JTO.0b013e3182829e06. PubMed PMID: 23370366.

  28. Pandey P, Seshacharyulu P, Das S, Rachagani S, Ponnusamy MP, Yan Y, Johansson SL, Datta K, Fong Lin M, Batra SK. Impaired expression of protein phosphatase 2A subunits enhances metastatic potential of human prostate cancer cells through activation of AKT pathway. Br J Cancer. 2013 Jun 25;108(12):2590-600. doi: 10.1038/bjc.2013.160. Epub 2013 Apr 18. PubMed PMID: 23598299; PubMed Central PMCID: PMC3694226.

  29. Jain M, Gupta S, Kaur S, Ponnusamy MP, Batra SK. Emerging trends for radioimmunotherapy in solid tumors. Cancer Biother Radiopharm. 2013 Nov;28(9):639-50. doi: 10.1089/cbr.2013.1523. Epub 2013 Jul 11. Review. PubMed PMID: 23844555; PubMed Central PMCID: PMC3793648.

  30. Ponnusamy MP, Seshacharyulu P, Lakshmanan I, Vaz AP, Chugh S, Batra SK. Emerging role of mucins in epithelial to mesenchymal transition. Curr Cancer Drug Targets. 2013 Nov;13(9):945-56. doi: 10.2174/15680096113136660100. Review. PubMed PMID: 24168188; PubMed Central PMCID: PMC3924542.


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