Melina Schuh

Dr. Melina Schuh was a Group Leader at the MRC Laboratory of Molecular Biology in Cambridge, the United Kingdom, after acquiring a PhD from the University of Heidelberg and the European Molecular Biology Laboratory (EMBL) in 2008. At the LMB, her group carried out the first studies of meiosis in live human oocytes and developed strategies for high content screens for meiotic genes in mammals. Since 2016, she became a Director at the Max Planck Institute for Biophysical Chemistry in Göttingen, Germany, where she leads the Department of Meiosis, continuing her lasting interest in that area. Her laboratory studies how errors arise during the meiotic divisions of mammalian eggs, and what causes the age-related decline in female fertility. The Schuh lab also developed a new method for the acute degradation of endogenous proteins, called Trim-Away, to aid the future research into the mammalian oocytes.

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Max Planck Institute for Biophysical Chemistry

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Meiosis 0 Mammalian Oocytes 0 Chromosomal Disorder 0 Molecular Biology 0 Genetics 0 Gene Editing 0

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  1. ElInati E, Zielinska AP, McCarthy A, et al. The BCL-2 pathway preserves mammalian genome integrity by eliminating recombination-defective oocytes. Nat Commun. 2020;11(1):2598. Published 2020 May 25. doi:10.1038/s41467-020-16441-z

  2. Zielinska AP, Bellou E, Sharma N, et al. Meiotic Kinetochores Fragment into Multiple Lobes upon Cohesin Loss in Aging Eggs. Curr Biol. 2019;29(22):3749-3765.e7. doi:10.1016/j.cub.2019.09.006

  3. Gruhn JR, Zielinska AP, Shukla V, et al. Chromosome errors in human eggs shape natural fertility over reproductive life span. Science. 2019;365(6460):1466-1469. doi:10.1126/science.aav7321

  4. So C, Seres KB, Steyer AM, et al. A liquid-like spindle domain promotes acentrosomal spindle assembly in mammalian oocytes. Science. 2019;364(6447):eaat9557. doi:10.1126/science.aat9557

  5. Clift D, So C, McEwan WA, James LC, Schuh M. Publisher Correction: Acute and rapid degradation of endogenous proteins by Trim-Away. Nat Protoc. 2019;14(8):2596. doi:10.1038/s41596-018-0092-8

  6. Uraji J, Scheffler K, Schuh M. Functions of actin in mouse oocytes at a glance. J Cell Sci. 2018;131(22):jcs218099. Published 2018 Nov 22. doi:10.1242/jcs.218099

  7. Zielinska AP, Schuh M. A microscopy-based approach for studying meiosis in live and fixed human oocytes. Methods Cell Biol. 2018;145:315-333. doi:10.1016/bs.mcb.2018.03.039


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