Marc Ostermeier

Dr. Marc Ostermeier received his B.S. in Chemical Engineering from the University of Wisconsin-Madison in 1990 and his Ph.D. from the University of Texas at Austin in 1996. He was an NIH postdoctoral fellow at Pennsylvania State University from 1996 to 2000. Dr. Ostermeier’s lab seeks insight into the principles of natural evolution and the ability to design novel proteins and cells using laboratory evolution. For example, the creation of artificial protein switches is an important goal of protein engineering. Switches that establish connections between cellular components with no previous relationship can result in novel cellular circuitry and phenotypes. Such switches might establish connections between molecular signatures of disease and functions that serve to treat the disease and therefore possess selective therapeutic properties.

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Johns Hopkins University

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Protein Engineering 0 Evolution 0 Synthetic Biology 0

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  1. Ostermeier, Marc, Jae Hoon Shim, and Stephen J. Benkovic. "A combinatorial approach to hybrid enzymes independent of DNA homology." Nature biotechnology 17.12 (1999): 1205-1209.

  2. Lutz, Stefan, et al. "Creating multiple-crossover DNA libraries independent of sequence identity." Proceedings of the National Academy of Sciences 98.20 (2001): 11248-11253.

  3. Guntas, Gurkan, et al. "Directed evolution of protein switches and their application to the creation of ligand-binding proteins." Proceedings of the National Academy of Sciences 102.32 (2005): 11224-11229.

  4. Firnberg, Elad, et al. "A comprehensive, high-resolution map of a gene’s fitness landscape." Molecular biology and evolution 31.6 (2014): 1581-1592.

  5. Ostermeier, Marc, et al. "Combinatorial protein engineering by incremental truncation." Proceedings of the National Academy of Sciences 96.7 (1999): 3562-3567.

  6. Sohka, Takayuki, et al. "An externally tunable bacterial band-pass filter." Proceedings of the National Academy of Sciences 106.25 (2009): 10135-10140.


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