Longhou Fang
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Houston Methodist, Weill Cornell Medical College
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Angiogenesis 0 Lymphangiogenesis 0 Hematopoiesis 0 Cholesterol metabolism 0
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Neutralizing antibodies (NAbs) are critical human immune defense mechanisms against viral infections. NAbs can bind to sites on the virus and inhibit entry of that virus into the host. It is a key parameter to evaluate COVID-19 vaccine efficacy per Guidelines from Development and ...Learn More
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This 3D animation shows you how DNA is copied in a cell. It shows how both strands of the DNA helix are unzipped and copied to produce two identical DNA molecules. TranscriptDNA is a molecule made up of two strands twisted around each other in a double helix shape. Each strand is ...Learn More
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Combination of apolipoprotein-A-I/apolipoprotein-A-I binding protein and anti-VEGF treatment overcomes anti-VEGF resistance in choroidal neovascularization in mice
Zhu, L, Parker, M, Enemchukwu, N, Shen, M, Zhang, G, Yan, Q, Handa, JT, Fang, L & Fu, Y 2020, , Communications Biology, vol. 3, no. 1, 386.
Hematopoiesis is regulated by cholesterol efflux pathways and lipid rafts: Connections with cardiovascular diseases
Morgan, PK, Fang, L, Lancaster, GI & Murphy, AJ 2020, , Journal of lipid research, vol. 61, no. 5, pp. 667-675.
Regulation of lipid rafts, angiogenesis and inflammation by AIBP
Fang, L & Miller, YI 2019, , Current opinion in lipidology, vol. 30, no. 3, pp. 218-223.
4. AIBP-mediated cholesterol efflux instructs hematopoietic stem and progenitor cell fate
Gu, Q, Yang, X, Lv, J, Zhang, J, Xia, B, Kim, JD, Wang, R, Xiong, F, Meng, S, Clements, TP, Tandon, B, Wagner, DS, Diaz, MF, Wenzel, PL, Miller, YI, Traver, D, Cooke, JP, Li, W, Zon, LI, Chen, K, Bai, Y & Fang, L 2019, , Science, pp. eaav1749.
5. TBX20 Regulates Angiogenesis Through the Prokineticin 2-Prokineticin Receptor 1 Pathway
Meng, S, Gu, Q, Yang, X, Lv, J, Owusu, I, Matrone, G, Chen, K, Cooke, JP & Fang, L 2018, , Circulation, vol. 138, no. 9, pp. 913-928.
6. AIBP augments cholesterol efflux from alveolar macrophages to surfactant and reduces acute lung inflammation
Choi, SH, Wallace, AM, Schneider, DA, Burg, E, Kim, J, Alekseeva, E, Ubags, ND, Cool, CD, Fang, L, Suratt, BT & Miller, YI 2018, , JCI insight, vol. 3, no. 16.
7. AIBP protects against metabolic abnormalities and atherosclerosis
Schneider, DA, Choi, SH, Agatisa-Boyle, C, Zhu, L, Kim, J, Pattison, J, Sears, DD, Gordts, PLSM, Fang, L & Miller, YI 2018, , Journal of lipid research, vol. 59, no. 5, pp. 854-863.
8. A minimally invasive approach to induce myocardial infarction in mice without thoracotomy
Sun, Q, Wang, KK, Pan, M, Zhou, JP, Qiu, XT, Wang, ZY, Yang, Z, Chen, Y, Shen, H, Gu, QL, Fang, LH, Zhang, GG & Bai, YP 2018, , Journal of Cellular and Molecular Medicine, vol. 22, no. 11, pp. 5208-5219. https://doi.org/10.1111/jcmm.13708
9. Lmo2 (LIM-Domain-Only 2) Modulates Sphk1 (Sphingosine Kinase) and Promotes Endothelial Cell Migration
Matrone, G, Meng, S, Gu, Q, Lv, J, Fang, L, Chen, K & Cooke, JP 2017, , Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 37, no. 10, pp. 1860-1868.
10. AIBP Limits Angiogenesis Through ?-Secretase-Mediated Upregulation of Notch Signaling
Mao, R, Meng, S, Gu, Q, Araujo-Gutierrez, R, Kumar, S, Yan, Q, Almazan, F, Youker, KA, Fu, Y, Pownall, HJ, Cooke, JP, Miller, YI & Fang, L 2017, , Circulation Research, vol. 120, no. 11, pp. 1727-1739.
11. AIBP: A Novel Molecule at the Interface of Cholesterol Transport, Angiogenesis, and Atherosclerosis
Zhu, L & Fang, L 2015, , Methodist DeBakey cardiovascular journal, vol. 11, no. 3, pp. 160-165.
12. Polo-like kinase 2 regulates angiogenic sprouting and blood vessel development
Yang, H, Fang, L, Zhan, R, Hegarty, JM, Ren, J, Hsiai, TK, Gleeson, JG, Miller, YI, Trejo, JA & Chi, NC 2015, , Developmental Biology, vol. 404, no. 2, pp. 49-60.
13. Apoc2 loss-of-function zebrafish mutant as a genetic model of hyperlipidemia
Liu, C, Gates, KP, Fang, L, Amar, MJ, Schneider, DA, Geng, H, Huang, W, Kim, J, Pattison, J, Zhang, J, Witztum, JL, Remaley, AT, Dong, PD & Miller, YI 2015, , DMM Disease Models and Mechanisms, vol. 8, no. 8, pp. 989-998.
14. Oxidative stress activates endothelial innate immunity via sterol regulatory element binding protein 2 (SREBP2) transactivation of MicroRNA-92a
Chen, Z, Wen, L, Martin, M, Hsu, CY, Fang, L, Lin, FM, Lin, TY, Geary, MJ, Geary, GG, Zhao, Y, Johnson, DA, Chen, JW, Lin, SJ, Chien, S, Huang, HD, Miller, YI, Huang, PH & Shyy, JYJ 2015, , Circulation, vol. 131, no. 9, pp. 805-814.
15. Zebrafish models of dyslipidemia: Relevance to atherosclerosis and angiogenesis
Fang, L, Liu, C & Miller, YI 2014, , Translational Research, vol. 163, no. 2, pp. 99-108.
16. Targeted cholesterol efflux
Fang, L & Miller, YI 2013, , Cell Cycle, vol. 12, no. 21, pp. 3345-3346.
17. Control of angiogenesis by AIBP-mediated cholesterol efflux
Fang, L, Choi, SH, Baek, JS, Liu, C, Almazan, F, Ulrich, F, Wiesner, P, Taleb, A, Deer, E, Pattison, J, Torres-Vázquez, J, Li, AC & Miller, YI 2013, , Nature, vol. 498, no. 7452, pp. 118-122.
18. Emerging applications for zebrafish as a model organism to study oxidative mechanisms and their roles in inflammation and vascular accumulation of oxidized lipids
Fang, L & Miller, YI 2012, , Free Radical Biology and Medicine, vol. 53, no. 7, pp. 1411-1420.
19. Ezetimibe and simvastatin reduce cholesterol levels in zebrafish larvae fed a high-cholesterol diet
Baek, JS, Fang, L, Li, AC & Miller, YI 2012, , Cholesterol, vol. 2012, 564705.
20. In vivo visualization and attenuation of oxidized lipid accumulation in hypercholesterolemic zebrafish
Fang, L, Green, SR, Baek, JS, Lee, SH, Ellett, F, Deer, E, Lieschke, GJ, Witztum, JL, Tsimikas, S & Miller, YI 2011, , Journal of Clinical Investigation, vol. 121, no. 12, pp. 4861-4869.
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