Laurence Zitvogel

Pr L. Zitvogel, MD (clinical oncology), PhD (tumor immunology), PU-PH Faculty Paris Sud, University Paris XI (Clinical Biology), graduated in Medical Oncology from the School of Medicine of the University of Paris in 1992. She started her scientific career when she was at the University of Pittsburgh in the USA in Michael Lotze’s laboratory. She became Research Director at Institute of National Sante at Research Medical U1015, in a laboratory located at Institute Gustave Roussy, a large cancer Center in Villejuif/France and the Head of the Center for Clinical Investigations CICBT 507 for vaccine developments at Villejuif. Her expertise is mainly dendritic cell and innate effector biology and relevance during tumour development as well as exosome-based vaccine designs. She pioneered the concept of immunogenic cell death and showed that chemotherapy, radiotherapy and inhibitors of tyrosine kinase mediate their tumoricidal activity, at least partly through the immune system. She is currently working on the mode of action of immune checkpoint blockers.

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Institut Gustave Roussy

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Immunotherapy 0 Immune Checkpoint Blockade, Immunogenic Cell Death 0 Clinical Oncology 0 Chemotherapy Immune Checkpoint Blockade 0 Immunogenic Cell Death 0 Chemotherapy 0

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  1. Finlay BB, Goldszmid R, Honda K, Trinchieri G, Wargo J, Zitvogel L. Can we harness the microbiota to enhance the efficacy of cancer immunotherapy? [published online ahead of print, 2020 Jul 13]. Nat Rev Immunol. 2020;10.1038/s41577-020-0374-6. doi:10.1038/s41577-020-0374-6

  2. Kroemer G, Zitvogel L. Seeking Cellular Fitness and Immune Evasion: Autophagy in Pancreatic Carcinoma. Cancer Cell. 2020;37(6):759-760. doi:10.1016/j.ccell.2020.05.009

  3. Roberti MP, Yonekura S, Duong CPM, et al. Chemotherapy-induced ileal crypt apoptosis and the ileal microbiome shape immunosurveillance and prognosis of proximal colon cancer. Nat Med. 2020;26(6):919-931. doi:10.1038/s41591-020-0882-8

  4. Zumla A, Wang FS, Ippolito G, et al. Reducing mortality and morbidity in patients with severe COVID-19 disease by advancing ongoing trials of Mesenchymal Stromal (stem) Cell (MSC) therapy - Achieving global consensus and visibility for cellular host-directed therapies. Int J Infect Dis. 2020;96:431-439. doi:10.1016/j.ijid.2020.05.040

  5. Derosa L, Routy B, Fidelle M, et al. Gut Bacteria Composition Drives Primary Resistance to Cancer Immunotherapy in Renal Cell Carcinoma Patients. Eur Urol. 2020;78(2):195-206. doi:10.1016/j.eururo.2020.04.044

  6. Galluzzi L, Vitale I, Warren S, et al. Consensus guidelines for the definition, detection and interpretation of immunogenic cell death [published correction appears in J Immunother Cancer. 2020 May;8(1):]. J Immunother Cancer. 2020;8(1):e000337. doi:10.1136/jitc-2019-000337


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