Kevin Roy
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Neutralizing antibodies (NAbs) are critical human immune defense mechanisms against viral infections. NAbs can bind to sites on the virus and inhibit entry of that virus into the host. It is a key parameter to evaluate COVID-19 vaccine efficacy per Guidelines from Development and ...Learn More
This 3D animation shows you how DNA is copied in a cell. It shows how both strands of the DNA helix are unzipped and copied to produce two identical DNA molecules. TranscriptDNA is a molecule made up of two strands twisted around each other in a double helix shape. Each strand is ...Learn More
IntroductionA gleam of light finally shone down on the global crisis of the prolonged battle against COVID-19, giving people hopes of preventive care and treatment in the near future by monoclonal antibodies against SARS-CoV-2. As stated the news of NIH’s phase III clinical ...Learn More
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In recent years there is an increasing number of cytotoxic chemotherapeutic compounds with the ability to rapidly kill dividing cancer cells in preference to non-dividing healthy cells. Nevertheless, the major drawback of chemotherapy is that, in addition to damaging the cancer ...Learn More
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An Evaluation of High-Throughput Approaches to QTL Mapping in Saccharomyces cerevisiae. Wilkening, S., Lin, G., Fritsch, E.S., Tekkedil, M.M., Anders, S., Kuehn, R., Nguyen, M., Aiyar, R.S., Proctor, M., Sakhanenko, N.A., Galas, D.J., Gagneur, J., Deutschbauer, A. & Steinmetz, L.M. Genetics (2013) PubMed | DOI
Genotype-environment interactions reveal causal pathways that mediate genetic effects on phenotype. Gagneur, J., Stegle, O., Zhu, C., Jakob, J., Tekkedil, M.M., Aiyar, R.S., Schuon, A.K., Pe’er, D. & Steinmetz, L.M. PLoS Genetics (2013) PubMed | DOI
Extensive transcriptional heterogeneity revealed by isoform profiling. Pelechano, V., Wei, W. & Steinmetz, L.M. Nature (2013) Apr 24. PubMed | DOI
The Genomic and Transcriptomic Landscape of a HeLa Cell Line. Landry, J.J., Pyl, P.T., Rausch, T., Zichner, T., Tekkedil, M.M., Stütz, A.M., Jauch, A., Aiyar, R.S., Pau, G., Delhomme, N., Gagneur, J., Korbel, J.O., Huber, W. & Steinmetz, L.M. G3: Genes | Genomes | Genetics (2013) Mar 26. PubMed | DOI
Experimental relocation of the mitochondrial ATP9 gene to the nucleus reveals forces underlying mitochondrial genome evolution. Bietenhader, M., Martos, A., Tetaud, E., Aiyar, R.S., Sellem, C., Kucharczyk, R., Clauder-Muenster, S., Giraud, M.F., Godard, F., Salin, B., Sagot, I., Gagneur, J., Dequard-Chablat, M., Contamine, V., Hermann-Le Denmat, S., Sainsard-Chanet, A., Steinmetz, L.M.* & di Rago, J.P.* PLoS Genet. (2012) Aug 16. PubMed | DOI
Antisense expression increases gene expression variability and locus interdependency. Xu, Z., Wei, W., Gagneur, J., Clauder-Muenster, S., Smolik, M., Huber, W. & Steinmetz, L.M. Mol. Systems Biology (2011) Feb 15;7:468. PubMed | DOI | F1000 Evaluation
Dissecting the genetic basis of resistance to malaria parasites in Anopheles gambiae. Blandin, S.A., Wang-Sattler, R., Lamacchia, M., Gagneur, J., Lycett, G., Ning, Y., Levashina, E.A. & Steinmetz, L.M. Science (2009) 326:147–150. PubMed | DOI
Bidirectional promoters generate pervasive transcription in yeast. Xu, Z., Wei, W., Gagneur, J., Perocchi, F., Clauder-Muenster, S., Camblong, J., Guffanti, E., Stutz, F., Huber, W., & Steinmetz, L.M. Nature (2009) 457, 1033–1037. PubMed | DOI
High-resolution mapping of meiotic crossovers and noncrossovers in yeast. Mancera, E., Bourgon, R., Brozzi, A., Huber, W. & Steinmetz, L.M. Nature 454, 479–485 (2008). PubMed | DOI | F1000 Evaluation
A high-resolution map of transcription in the yeast genome. David, L., Huber, W., Granovskaia, M., Toedling, J., Palm, C. J., Bofkin, L., Jones, T., Davis R.W. & Steinmetz, L.M. Proc. Natl. Acad. Sci. USA (2006) 103, 5320–5325. PubMed | DOI | F1000 Evaluation
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