Kevin Roy

Kevin obtained his Ph.D. in Molecular Biology in the laboratory of Dr. Guillaume Chanfreau at UCLA. There he studied environment-dependent RNA degradation pathways in yeast, and developed high-throughput methods to map sites of RNA degradation by nuclear RNA endonucleases. He has a strong background in yeast genetics and molecular biology, as well as in high-throughput sequencing techniques and data analysis. His current interests include quantitative and systems genetics, with a focus on how genetic variation interacts with the environment to produce cellular phenotypes. At Stanford, he will study the consequences of single-nucleotide variants at the genome-wide scale, in order to provide insight into evolutionary processes and how environmental conditions suppress or enhance the effects of genetic variation.

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Stanford University

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  1. An Evaluation of High-Throughput Approaches to QTL Mapping in Saccharomyces cerevisiae. Wilkening, S., Lin, G., Fritsch, E.S., Tekkedil, M.M., Anders, S., Kuehn, R., Nguyen, M., Aiyar, R.S., Proctor, M., Sakhanenko, N.A., Galas, D.J., Gagneur, J., Deutschbauer, A. & Steinmetz, L.M. Genetics (2013) PubMed | DOI

  2. Genotype-environment interactions reveal causal pathways that mediate genetic effects on phenotype. Gagneur, J., Stegle, O., Zhu, C., Jakob, J., Tekkedil, M.M., Aiyar, R.S., Schuon, A.K., Pe’er, D. & Steinmetz, L.M. PLoS Genetics (2013) PubMed | DOI

  3. Extensive transcriptional heterogeneity revealed by isoform profiling. Pelechano, V., Wei, W. & Steinmetz, L.M. Nature (2013) Apr 24. PubMed | DOI

  4. The Genomic and Transcriptomic Landscape of a HeLa Cell Line. Landry, J.J., Pyl, P.T., Rausch, T., Zichner, T., Tekkedil, M.M., Stütz, A.M., Jauch, A., Aiyar, R.S., Pau, G., Delhomme, N., Gagneur, J., Korbel, J.O., Huber, W. & Steinmetz, L.M. G3: Genes | Genomes | Genetics (2013) Mar 26. PubMed | DOI

  5. Experimental relocation of the mitochondrial ATP9 gene to the nucleus reveals forces underlying mitochondrial genome evolution. Bietenhader, M., Martos, A., Tetaud, E., Aiyar, R.S., Sellem, C., Kucharczyk, R., Clauder-Muenster, S., Giraud, M.F., Godard, F., Salin, B., Sagot, I., Gagneur, J., Dequard-Chablat, M., Contamine, V., Hermann-Le Denmat, S., Sainsard-Chanet, A., Steinmetz, L.M.* & di Rago, J.P.* PLoS Genet. (2012) Aug 16. PubMed | DOI

  6. Antisense expression increases gene expression variability and locus interdependency. Xu, Z., Wei, W., Gagneur, J., Clauder-Muenster, S., Smolik, M., Huber, W. & Steinmetz, L.M. Mol. Systems Biology (2011) Feb 15;7:468. PubMed | DOI | F1000 Evaluation

  7. Dissecting the genetic basis of resistance to malaria parasites in Anopheles gambiae. Blandin, S.A., Wang-Sattler, R., Lamacchia, M., Gagneur, J., Lycett, G., Ning, Y., Levashina, E.A. & Steinmetz, L.M. Science (2009) 326:147–150. PubMed | DOI

  8. Bidirectional promoters generate pervasive transcription in yeast. Xu, Z., Wei, W., Gagneur, J., Perocchi, F., Clauder-Muenster, S., Camblong, J., Guffanti, E., Stutz, F., Huber, W., & Steinmetz, L.M. Nature (2009) 457, 1033–1037. PubMed | DOI

  9. High-resolution mapping of meiotic crossovers and noncrossovers in yeast. Mancera, E., Bourgon, R., Brozzi, A., Huber, W. & Steinmetz, L.M. Nature 454, 479–485 (2008). PubMed | DOI | F1000 Evaluation

  10. A high-resolution map of transcription in the yeast genome. David, L., Huber, W., Granovskaia, M., Toedling, J., Palm, C. J., Bofkin, L., Jones, T., Davis R.W. & Steinmetz, L.M. Proc. Natl. Acad. Sci. USA (2006) 103, 5320–5325. PubMed | DOI | F1000 Evaluation

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