Dr. Jonathan Gootenberg earned his bachelor’s degree in mathematics and biological engineering at MIT. He received his PhD in Systems Biology from Harvard University, during which he conducted researches with Aviv Regev and Feng Zhang at the McGovern Institute and Broad Institute of MIT and Harvard. He is one of the first members of the McGovern Institute Fellows program, which aims to support the transition to independent research for exceptional recent PhD graduates. Dr. Jonathan Gootenberg explores biological diversity to develop tools for understanding and treating age-related disease. He draws from fundamental microbiology to engineer new molecular tools, which he applies to the study of aging. These tools, including the popular genome editing system CRISPR, allow for unprecedented manipulation and profiling of cellular states in the body, and have multiple applications in basic science, diagnostics, and therapeutics. Along with McGovern Fellow Omar Abudayyeh, Gootenberg uses gene editing, gene delivery, and cellular profiling methods to understand the changes that occur in the brain and other organs during aging, with the goal of generating new therapies for degenerative disease.
Research Area and Skills
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Aging 0 Molecular Tools 0 Gene Editing 0 Gene Delivery 0 Degenerative Disease 0 Diagnostics 0 Therapeutics 0
Joung, J., Ladha, A., Saito, M., Segel, M., Bruneau, R., Huang, M. L. W., ... & Greninger, A. L. (2020). Point-of-care testing for COVID-19 using SHERLOCK diagnostics. medRxiv.
Abudayyeh, O. O., Gootenberg, J. S., Essletzbichler, P., Han, S., Joung, J., Belanto, J. J., ... & Lander, E. S. (2017). RNA targeting with CRISPR–Cas13. Nature, 550(7675), 280-284.
Gootenberg, J. S., Abudayyeh, O. O., Lee, J. W., Essletzbichler, P., Dy, A. J., Joung, J., ... & Myhrvold, C. (2017). Nucleic acid detection with CRISPR-Cas13a/C2c2. Science, 356(6336), 438-442.
Abudayyeh, O. O., Gootenberg, J. S., Konermann, S., Joung, J., Slaymaker, I. M., Cox, D. B., ... & Severinov, K. (2016). C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector. Science, 353(6299).