Jason W. Chin

Prof. Jason Chin acquired a PhD degree as a Fulbright grantee at Yale University, and He was a Damon Runyon Fellow at The Scripps Research Institute where he developed the first approaches to systematically expand the genetic code of eukaryotic cells and pioneered approaches, that are now widely used, for defining protein interactions by genetically encoding photocrosslinking amino acids. Chin is currently Programme Leader at the Medical Research Council Laboratory of Molecular Biology (MRC-LMB) at Cambridge, the United Kingdom, where he is also Head of the Centre for Chemical & Synthetic Biology (CCSB). The Chin lab is leading the research on the systematic genetic code reprogramming in living organisms, and by utilizing the new approaches developed, the team is able to make designated incorporation of designer unnatural amino acids into proteins. Starting from the very initial design of orthogonal ribosome, then the investigation of post-translational modifications, and the optogenetic means that enable a rapid control of enzymatic activity and protein transport in cells, to the final site-specific labelling hence detection of proteins using small molecule flurophores in vivo, Prof. Chin and his team conduct comprehensive research into the genetic reprogramming. They recently managed to expand the genetic code of two established multicellular model organisms, C. elegans and D. melanogaster. By applying the approaches the lab has created in cells for controlling and imaging protein function in whole animals they hope to provide new insight into processes, including embryonic development, tissue morphogenesis, tumor biology and neuronal plasticity, that can only be studied at the organism level.

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Medical Research Council Laboratory of Molecular Biology/ Chemical & Synthetic Biology

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Molecular Biology 0 Synthetic Biology 0 Genetic Code Reprogramming 0 Optogenetics 0 Protein Synthesis 0 Translation Pathways 0 Post-Translational Modifications 0

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  1. Dunkelmann, D.L., Willis, J.C.W., Beattie, A.T. et al. Engineered triply orthogonal pyrrolysyl–tRNA synthetase/tRNA pairs enable the genetic encoding of three distinct non-canonical amino acids. Nat. Chem. 12, 535–544 (2020).

  2. Cervettini, D., Tang, S., Fried, S.D. et al. Rapid discovery and evolution of orthogonal aminoacyl-tRNA synthetase–tRNA pairs. Nat Biotechnol (2020).

  3. Hodskinson, M.R., Bolner, A., Sato, K. et al. Alcohol-derived DNA crosslinks are repaired by two distinct mechanisms. Nature 579, 603–608 (2020).

  4. Wang K, de la Torre D, Robertson WE, Chin JW. Programmed chromosome fission and fusion enable precise large-scale genome rearrangement and assembly. Science. 2019;365(6456):922-926.

  5. Oller-Salvia B, Chin JW. Efficient Phage Display with Multiple Distinct Non-Canonical Amino Acids Using Orthogonal Ribosome-Mediated Genetic Code Expansion. Angew Chem Int Ed Engl. 2019;58(32):10844-10848.

  6. Fredens J, Wang K, de la Torre D, et al. Total synthesis of Escherichia coli with a recoded genome. Nature. 2019;569(7757):514-518.


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