Jan Kosinski

Jan Kosinski obtained his PhD degree from the International Institute of Molecular and Cell Biology, Warsaw, Poland in 2009, and worked as postdoctoral researcher afterwards at “Sapienza” University, Rome, and EMBL Heidelberg respectively. He is now a group leader at EMBL Hamburg. Dr Kosinski is specialised in the bioinformatics and modelling of biological systems; the Kosinski group investigates nuclear pore and other complexes, infection cycles, and host-pathogen interactions using computational and experimental approaches. Ongoing projects in his lab are primarily integrative modelling of biological entities, and for the side of structural modelling of macromolecular complexes, they have built a near-atomic model of one of the largest complexes in the cell – the human nuclear pore complex – based on data from electron tomography and cross-linking mass spectrometry. Currently they are applying principles of modelling molecules to the entire pathways, for instance viral infection cycles. They aim to gain more insights about host-pathogen interactions and identify which of them are the most crucial for infection.

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EMBL Hamburg

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Proteomics 0 Bioinformatics 0 Systems Biology 0 Molecular Structural Modelling 0 Biological Pathway Modelling 0 Viral Infection Cycles 0

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  1. Glazinska P, Kulasek M, Glinkowski W, Wysocka M, Kosiński JG. LuluDB-The Database Created Based on Small RNA, Transcriptome, and Degradome Sequencing Shows the Wide Landscape of Non-coding and Coding RNA in Yellow Lupine (Lupinus luteus L.) Flowers and Pods. Front Genet. 2020;11:455. Published 2020 May 15. doi:10.3389/fgene.2020.00455

  2. Glazinska P, Kulasek M, Glinkowski W, Wysocka M, Kosiński JG. LuluDB-The Database Created Based on Small RNA, Transcriptome, and Degradome Sequencing Shows the Wide Landscape of Non-coding and Coding RNA in Yellow Lupine (Lupinus luteus L.) Flowers and Pods. Front Genet. 2020;11:455. Published 2020 May 15. doi:10.3389/fgene.2020.00455

  3. Dauden MI, Jaciuk M, Weis F, et al. Molecular basis of tRNA recognition by the Elongator complex. Sci Adv. 2019;5(7):eaaw2326. Published 2019 Jul 10. doi:10.1126/sciadv.aaw2326

  4. Ural-Blimke Y, Flayhan A, Strauss J, et al. Structure of Prototypic Peptide Transporter DtpA from E. coli in Complex with Valganciclovir Provides Insights into Drug Binding of Human PepT1. J Am Chem Soc. 2019;141(6):2404-2412. doi:10.1021/jacs.8b11343

  5. Mosalaganti S, Kosinski J, Albert S, et al. In situ architecture of the algal nuclear pore complex. Nat Commun. 2018;9(1):2361. Published 2018 Jun 18. doi:10.1038/s41467-018-04739-y


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