James Chong

Dr. James Chong obtained his Ph.D. at the Victor Chang Cardiac Research Institute, and he continued to Prof Charles Murry’s laboratory at the University of Washington for research in cardiac stem cells, where Chong managed to demonstrate human Pluripotent Stem Cell Derived Cardiomyocytes (hPSC-CM) can be produced in a large enough scale to treat non-human primates and that hPSC-CM can electrically integrate after transplantation into the injured heart. Currently, Chong is an Associate Professor at the University of Sydney, leading group research focusing on developing novel therapies for cardiovascular diseases and heart tegeneration. The daily experience as a cardiologist, of Dr. Chong, has been providing inspirations for the group. Recently, Dr. Chong’s group has found that delivery of recombinant human Platelet Derived Growth Factor (rhPDGF) in a clinically relevant large animal model of myocardial infarction substantially improves cardiac function and reduces rates of potentially lethal heart rhythm abnormalities; with results suggesting rhPDGF imparts these effects by changing the alignment of collagen fibres within the infarct scar.

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University of Sydney

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Heart regeneration 0 Therapeutic application of stem cells 0 Development of new therapies for heart disease 0 Coronary atherosclerosis and thrombosis 0

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  1. Thavapalachandran S, Grieve SM, Hume RD, et al. Platelet-derived growth factor-AB improves scar mechanics and vascularity after myocardial infarction. Sci Transl Med. 2020;12(524):eaay2140. doi:10.1126/scitranslmed.aay2140

  2. Farraha M, Barry MA, Lu J, et al. Analysis of recombinant adeno-associated viral vector shedding in sheep following intracoronary delivery. Gene Ther. 2019;26(9):399-406. doi:10.1038/s41434-019-0097-0

  3. White SJ, Chong JJH. Growth factor therapy for cardiac repair: an overview of recent advances and future directions [published online ahead of print, 2020 Jul 20]. Biophys Rev. 2020;10.1007/s12551-020-00734-0. doi:10.1007/s12551-020-00734-0

  4. Chong JJH, Prince RL, Thompson PL, et al. Association Between Plasma Neutrophil Gelatinase-Associated Lipocalin and Cardiac Disease Hospitalizations and Deaths in Older Women. J Am Heart Assoc. 2019;8(1):e011028. doi:10.1161/JAHA.118.011028

  5. Le TYL, Pickett HA, Yang A, et al. Enhanced cardiac repair by telomerase reverse transcriptase over-expression in human cardiac mesenchymal stromal cells. Sci Rep. 2019;9(1):10579. Published 2019 Jul 22. doi:10.1038/s41598-019-47022-w

  6. Le TYL, Ogawa M, Kizana E, Gunton JE, Chong JJH. Vitamin D Improves Cardiac Function After Myocardial Infarction Through Modulation of Resident Cardiac Progenitor Cells. Heart Lung Circ.


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