Fei Guo
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Chinese Academy of Medical Sciences and Peking Union Medical College
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CRISPR/Cas genome editing 0 Immune recognition 0 Virus 0
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Neutralizing antibodies (NAbs) are critical human immune defense mechanisms against viral infections. NAbs can bind to sites on the virus and inhibit entry of that virus into the host. It is a key parameter to evaluate COVID-19 vaccine efficacy per Guidelines from Development and ...Learn More
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This 3D animation shows you how DNA is copied in a cell. It shows how both strands of the DNA helix are unzipped and copied to produce two identical DNA molecules. TranscriptDNA is a molecule made up of two strands twisted around each other in a double helix shape. Each strand is ...Learn More
IntroductionA gleam of light finally shone down on the global crisis of the prolonged battle against COVID-19, giving people hopes of preventive care and treatment in the near future by monoclonal antibodies against SARS-CoV-2. As stated the news of NIH’s phase III clinical ...Learn More
"Those who do not know history are obliged to repeat it" This famous phrase that could be from any history teacher to his suspended students has been attributed to great figures in history such as Napoleon or the philosopher George Santayana. In a modern version of it we could say ...Learn More
In recent years there is an increasing number of cytotoxic chemotherapeutic compounds with the ability to rapidly kill dividing cancer cells in preference to non-dividing healthy cells. Nevertheless, the major drawback of chemotherapy is that, in addition to damaging the cancer ...Learn More
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The previous article on precision medicine was focused on Pharmacogenomics as a fundamental aspect of cancer therapeutics. In this sequel, emphasis would be on the role of immuno-oncology in personalization of cancer therapy, citing anti PD therapy as an example with hypothetical ...Learn More
CRISPR-Cas13a Inhibits HIV-1 Infection. Yin L, Zhao F, Sun H, Wang Z, Huang Y, Zhu W, Xu F, Mei S, Liu X, Zhang D, Wei L, Cen S, Hu S, Liang C, Guo F. Mol Ther Nucleic Acids. 2020 Jun 1;21:147-155. doi: 10.1016/j.omtn.2020.05.030.
CRISPR/Cas9 Inhibits Multiple Steps of HIV-1 Infection. Yin L, Hu S, Mei S, Sun H, Xu F, Li J, Zhu W, Liu X, Zhao F, Zhang D, Cen S, Liang C, Guo F. Hum Gene Ther. 2018 Nov;29(11):1264-1276
HIV-1 employs multiple mechanisms to resist Cas9/sgRNA targeting the viral primer binding site. Wang Z, Wang W, Cui YC, Pan Q, Zhu W, Gendron P, Guo F, Cen S, Witcher M, Liang C. J Virol. 2018 Aug 1. pii: JVI.01135-18. doi: 10.1128/JVI.01135-18.
CRISPR/Cas9-derived mutations both inhibit HIV-1 replication and accelerate viral escape. Wang Z, Pan Q, Gendron P, Zhu W, Guo F, Cen S, Wainberg MA, Liang C. Cell reports 2016：15, 1–9.
The CRISPR/Cas9 system inactivates latent HIV-1 proviral DNA. Zhu W, Lei R, Le Duff Y, Li J, Guo F, Wainberg MA, Liang C. Retrovirology. 2015 Feb 27;12(1):22. doi: 10.1186/s12977-015-0150-z.
Innate immune recognition and restriction factors:
A Nuclear Export Signal Is Required for cGAS to Sense Cytosolic DNA. Sun H,Yu Huang, Mei S, Xu F, Liu X, Zhao F, Yin L, Zhang D, Wei L, Wu C, Ma S, Wang J, Cen S, Liang C, Hu S, Guo F. Cell Reports, 2021
HIV-1 resists MxB inhibition of viral Rev protein. Wang Z, Chai K, Liu Q, Yi DR, Pan Q, Huang Y, Tan J, Qiao W, Guo F, Cen S, Liang C. Emerg Microbes Infect. 2020 Sep 1:1-44. doi: 10.1080/22221751.2020.1818633. Online ahead of print. PMID: 32873191
Activation and evasion of type I interferon responses by SARS-CoV-2. Lei X, Dong X, Ma R, Wang W, Xiao X, Tian Z, Wang C, Wang Y, Li L, Ren L, Guo F, Zhao Z, Zhou Z, Xiang Z, Wang J. Nat Commun. 2020 Jul 30;11(1):3810. doi: 10.1038/s41467-020-17665-9.
Chemokine (C-X-C motif) Ligand 4 is a Restrictor of Respiratory Syncytial Virus Infection and an Indicator of Clinical Severity. Han Z, Rao J, Xie Z, Wang C, Xu B, Qian S, Wang Y, Zhu J, Yang B, Xu F, Lei X, Guo F, Zhao Z, Ren L, Wang J. Am J Respir Crit Care Med. 2020 Jun 16. doi: 10.1164/rccm.201908-1567OC.
Pro-515 of the Dynamin-Like GTPase MxB Contributes to HIV-1 Inhibition by Regulating MxB Oligomerization and Binding to HIV-1 Capsid. Xu F, Zhao F, Zhao X, Zhang D, Liu X, Hu S, Mei S, Fan Z, Huang Y, Sun H, Wei L, Wu C, Li Q, Wang J, Cen S, Liang C, Guo F. J Biol Chem. 2020 May 8;295(19):6447-6456. doi: 10.1074/jbc.RA119.012439. Epub 2020 Mar 26.
PKR-dependent cytosolic cGAS foci are necessary for intracellular DNA sensing. Hu S, Sun H, Yin L, Li J, Mei S, Xu F, Wu C, Liu X, Zhao F, Zhang D, Huang Y, Ren L, Cen S, Wang J, Liang C, Guo F. Sci Signal. 2019 Nov 26;12(609). pii: eaav7934. doi: 10.1126/scisignal.aav7934.
Influenza Virus Exploits an Interferon-Independent lncRNA to Preserve Viral RNA Synthesis through Stabilizing Viral RNA Polymerase PB1. Wang J, Zhang Y, Li Q, Zhao J, Yi D, Ding J, Zhao F, Hu S, Zhou J, Deng T, Li X, Guo F, Liang C, Cen S. Cell Rep. 2019 Jun 11;27(11):3295-3304.e4. doi: 10.1016/j.celrep.2019.05.036
MOV10 sequesters the RNP of influenza A virus in the cytoplasm and is antagonized by viral NS1 protein. Li J, Hu S, Xu F, Mei S, Liu X, Yin L, Zhao F, Zhao X, Sun H, Xiong Z, Zhang D, Cen S, Wang J, Liang C, Guo F. Biochem J. 2019 Feb 5;476(3):467-481. doi: 10.1042/BCJ20180754.
Human MxB inhibits the replication of HCV. Yi DR, An N, Liu ZL, Xu FW, Raniga K, Li QJ, Zhou R, Wang J, Zhang YX, Zhou JM, Zhang LL, An J, Qin CF, Guo F, Li XY, Liang C, Cen S. J Virol. 2018 Oct 17. pii: JVI.01285-18. doi: 10.1128/JVI.01285-18.
Host Long Noncoding RNA lncRNA-PAAN Regulates the Replication of Influenza A Virus. Wang J, Wang Y, Zhou R, Zhao J, Zhang Y, Yi D, Li Q, Zhou J, Guo F, Liang C, Li X, Cen S. Viruses. 2018 Jun 16;10(6). pii: E330. doi: 10.3390/v10060330
Identification of small molecule compounds targeting the interaction of HIV-1 Vif and human APOBEC3G by virtual screening and biological evaluation. Ma L, Zhang Z, Liu Z, Pan Q, Wang J, Li X, Guo F, Liang C, Hu L, Zhou J, Cen S. Sci Rep. 2018 May 23;8(1):8067. doi: 10.1038/s41598-018-26318-3
A highly conserved amino acid in VP1 regulates maturation of enterovirus 71. Zhang YX, Huang YM, Li QJ, Li XY, Zhou YD, Guo F, Zhou JM, Cen S. PLoS Pathog. 2017 Sep 22;13(9):e1006625.
Identification and characterization of loop7 motif and its role in regulating biological function of human APOBEC3G through molecular modeling and biological assay. Zhai C, Ma L, Zhang Z, Ding J, Wang J, Zhang Y, Li X, Guo F, Yu L, Zhou J, Cen S. Acta Pharm Sin B. 2017 Sep;7(5):571-582. doi: 10.1016/j.apsb.2017.05.002. Epub 2017 Jun 2.
BST-2 restricts IAV release and is countered by the viral M2 protein. Hu S, Yin L, Mei S, Li J, Xu F, Sun H, Liu X, Cen S, Liang C, Li A, Guo F. Biochem J. 2017 Feb 20;474(5):715-730. doi: 10.1042/BCJ20160861.
Distribution and characteristics of rodent picornaviruses in China. Du J, Lu L, Liu F, Su H, Dong J, Sun L, Zhu Y, Ren X, Yang F, Guo F, Liu Q, Wu Z, Jin Q. Sci Rep. 2016 Sep 29;6:34381. doi: 10.1038/srep34381.
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