Eric Gouaux

Eric Gouaux received his Ph.D. degree in Chemistry at Harvard University, and did postdoctoral studies at both Harvard and MIT. Dr. Gouaux joined OHSU in 2005 as a senior scientist and was appointed the Jennifer and Bernard Lacroute Endowed Chair in Neuroscience Research, in 2015. The research of Dr. Gouaux has an emphasis on the molecular mechanisms and organisations of neurotransmitter receptors and transporters at chemical synapses, as well as those of the hearing system, especially of the mechanoelectrical transduction (MET) process. His lab applies a host of structural and biophysical approaches, including single particle and tomographic cryo-electron microscopy, to aid their investigations. The ongoing projects of the lab have fostered new understanding. The MET channel opening is triggered by the steerocilic PCDH15-CDH23 ‘tip-links’, while the Gouaux Lab recently revealed architecture of the PCDH15-LHFPL5 complex, with LHFPL5 being a candidate subunit of the MET channel, localise mutations associated with deafness. This shed new light on how forces in the PCDH15 tether may be transduced into the stereocilia membrane.

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Vollum Institute, Oregon Health and Science University

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Neurotransmitter Receptors 0 Mechanoelectrical Transduction of Stereocilia 0 Cys-loop receptors 0 Acid Sensing Ion Channels 0 PCDH15-LHFPL5 complex 0

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  1. Coleman JA, Navratna V, Antermite D, Yang D, Bull JA, Gouaux E. Chemical and structural investigation of the paroxetine-human serotonin transporter complex [published online ahead of print, 2020 Jul 3]. Elife. 2020;9:e56427. doi:10.7554/eLife.56427

  2. Ivica J, Lape R, Jazbec V, et al. The intracellular domain of homomeric glycine receptors modulates agonist efficacy [published online ahead of print, 2020 Feb 19]. J Biol Chem. 2020;jbc.RA119.012358. doi:10.1074/jbc.RA119.012358

  3. Clark S, Elferich J, Gai J, et al. Strategy for Compositional Analysis of the Hair Cell Mechanotransduction Complex Using TIRF Microscopy. Microsc Microanal. 2019;25(Suppl 2):1266-1267. doi:10.1017/s1431927619007062

  4. Jones BE, Tovar KR, Goehring A, et al. Autoimmune receptor encephalitis in mice induced by active immunization with conformationally stabilized holoreceptors. Sci Transl Med. 2019;11(500):eaaw0044. doi:10.1126/scitranslmed.aaw0044

  5. Coleman JA, Yang D, Zhao Z, et al. Serotonin transporter-ibogaine complexes illuminate mechanisms of inhibition and transport. Nature. 2019;569(7754):141-145. doi:10.1038/s41586-019-1135-1

  6. Ge J, Elferich J, Goehring A, Zhao H, Schuck P, Gouaux E. Structure of mouse protocadherin 15 of the stereocilia tip link in complex with LHFPL5. Elife. 2018;7:e38770. Published 2018 Aug 2. doi:10.7554/eLife.38770


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