Dengke Ma

Dengke Ma received his PhD degree from the Johns Hopkins University Scholl of Medicine in 2009, and postdoctoral training at the Massachusetts Institute of Technology. The research of the Dengke Ma Lab focuses on the genetic factors that regulate life processes in dormancy and homeostatic responses to extreme physical and chemical conditions. Ma’s lab utilizes genetically tractable C. elegans mutants and unconventional model systems, for instance, Mangrove Killifish and ex vivo mammalian neural stem cells, as discovery tools to identify genes that encode proteins responsible for novel mechanisms underlying cytoprotection, cellular organelle dynamics and organismic homeostasis in physiology and behaviors. Ma and his group believes, that such knowledge of the nature of life at the extremes may foster novel means of cytoprotection, organ transplantation, reversible cryo-preservation and therapeutics, to treat metabolic, neurological and ischemic disorders.

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Cardiovascular Research Institute, University of California San Francisco

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C. elegans 0 Evolutionary Biology 0 Ischemic disorders 0 Biology at Extreme Conditions 0 Gene Engineering 0

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  1. Cui Z, Liu Y, Wan W, et al. Ethacrynic acid targets GSTM1 to ameliorate obesity by promoting browning of white adipocytes [published online ahead of print, 2020 May 12]. Protein Cell. 2020;10.1007/s13238-020-00717-7. doi:10.1007/s13238-020-00717-7

  2. Zhang Z, Bai M, Barbosa GO, et al. Broadly conserved roles of TMEM131 family proteins in intracellular collagen assembly and secretory cargo trafficking. Sci Adv. 2020;6(7):eaay7667. Published 2020 Feb 12. doi:10.1126/sciadv.aay7667

  3. Wong THM, Li X, Ma D, Sun J. HNTf2-Catalyzed Synthesis of Hydrodibenzofurans by an Epoxidation/Semipinacol Rearrangement Cascade. Org Lett. 2020;22(5):1951-1954. doi:10.1021/acs.orglett.0c00300

  4. Jiang W, Wei Y, Long Y, et al. A genetic program mediates cold-warming response and promotes stress-induced phenoptosis in C. elegans. Elife. 2018;7:e35037. Published 2018 Apr 17. doi:10.7554/eLife.35037

  5. Bai M, Vozdek R, Hnízda A, et al. Conserved roles of C. elegans and human MANFs in sulfatide binding and cytoprotection. Nat Commun. 2018;9(1):897. Published 2018 Mar 1. doi:10.1038/s41467-018-03355-0


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