David Veesler

Dr. David Veesler received his doctoral degree from Aix Marseille University in 2010. From 2011 to 2014, he worked as a Postdoctoral Fellow at the Scripps Research Institute. Since 2015, he has been working as an Assistant Professor at the Department of Biochemistry, University of Washington. Dr. Veesler’s main research interest is to tackle the structure of macromolecular machines of biological interest to understand the mechanisms underlying their functions. His research team use a multi-disciplinary approach involving cryo-electron microscopy and X-ray crystallography complemented by various biochemical and biophysical techniques to obtain multi-scale data ranging from atom to whole-cell.

Lab Information

The Veesler Lab, Department of Biochemistry, University of Washington

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SARS-CoV-2/COVID-19 0 membrane fusion activation 0 germline antibody binding to HIV envelope 0 Epstein-Barr virus inhibition 0 deltacoronavirus spike structure 0

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Protocol and Reagents for Pseudotyping Lentiviral Particles with SARS-CoV-2 Spike Protein for Neutralization Assays. Crawford KHD, Eguia R, Dingens AS, Loes AN, Malone KD, Wolf CR, Chu HY, Tortorici MA, Veesler D, Murphy M, Pettie D, King NP, Balazs AB, Bloom JD. Viruses (in press).

Structure, function and antigenicity of the SARS-CoV-2 spike glycoprotein. Walls AC, Park YJ, Tortorici MA, Wall A, McGuire AT and Veesler D. Cell (2020) 181(2):281-292.

Parks KR, MacCamy AJ, Trichka J, Gray M, Weidle C, Borst AJ, Khechaduri A, Takushi B, Agrawal P, Guenaga J, Wyatt RT, Coler R, LaBranche C, Montefiori DC, Veesler D, Pancera M, McGuire AT and Stamatatos L. Overcoming steric restrictions of VRC01 HIV-1 neutralizing antibodies through immunization. Cell Rep. (2019) 29(10):3060-3072.

Structures of MERS-CoV spike glycoprotein in complex with sialoside attachment receptors. Park YJ, Walls AC, Wang Z, Sauer MM, Li W, Tortorici MA, Bosch BJ, DiMaio F and Veesler D. Nat Struct Mol Biol. (2019) 26(12):1151-1157.

Dang HV, Chan YP, Park YJ, Snijder J, Da Silva SC, Vu B, Yan L, Feng YR, Rockx B, Geisbert TW, Mire CE, Broder CC and Veesler D. An antibody against the F glycoprotein inhibits Nipah and Hendra virus infections. Nat Struct Mol Biol. (2019) 26(10):980-987.

Tortorici MA, and Veesler D. Structural insights into coronavirus entry. Advances in Virus Research. (2019) 105:93-116.

Tortorici MA, Walls AC, Lang Y, Wang C, Li Z, Koerhuis D, Boons GJ, Bosch BJ, Rey FA, DeGroot RJ and Veesler D. Structural basis for human coronavirus attachment to sialic acid receptors. Nat Struct Mol Biol. (2019) 26(6):481-489.

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