Daniel Murphy

Dr Daniel J. Murphy is a Professor of the Beatson Institute for Cancer Research at the University of Glasgow. His research centred on the oncogenes-driven mutations necessary for cancer progression. The Murphy group used a synthetic lethal approach to identify kinases required by cells that overexpress c-Myc, our screen identified a number of metabolic regulators, suggesting that Myc-driven tumours may be particularly sensitive to disruption of metabolic checkpoints. They have developed a number of conditional transgenic mouse models of cancer that enable them to humanely track the entire course of early disease through tumour initiation and progression in situ, hence achieving a comprehensive mechanistic understanding for cancerous processes and evaluation of candidate therapies. In recent projects, the group investigated KRAS-Driven Tumourgenesis, and identified a clinically relevant signature for Early Progression in KRAS-Driven Lung Adenocarcinoma.

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Beatson Institute for Cancer Research, University of Glasgow

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Oncogenes 0 MYC proto-oncogene 0 Transgenic Mice 0 Genetic Engineering 0 RNAi 0

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  1. Bott, A. J. et al. (2019) Glutamine anabolism plays a critical role in pancreatic cancer by coupling carbon and nitrogen metabolism. Cell Reports, 29(5), 1287-1298.e6. (doi: 10.1016/j.celrep.2019.09.056) (PMID:31665640)

  2. Neidler, S. et al. (2019) Identification of a clinically relevant signature for early progression in KRAS-driven lung adenocarcinoma. Cancers, 11(5), 600. (doi: 10.3390/cancers11050600) (PMID:31032816)

  3. Scopelliti, A., Bauer, C. , Yu, Y., Zhang, T., Kruspig, B., Murphy, D. J. , Vidal, M., Maddocks, O. D.K. and Cordero, J. B. (2019) A neuronal relay mediates a nutrient responsive gut/fat body axis regulating energy homeostasis in adult Drosophila. Cell Metabolism, 29(2), 269-284.e10. (doi: 10.1016/j.cmet.2018.09.021) (PMID:30344016) (PMCID:PMC6370946)

  4. Muthalagu, N. and Murphy, D. J. (2018) Is oxidative stress MYC’s Achilles heel? Cell Death and Differentiation, 25(7), pp. 1189-1190. (doi: 10.1038/s41418-018-0117-4) (PMID:29844569)

  5. Kruspig, B. et al. (2018) The ERBB network facilitates KRAS-driven lung tumorigenesis. Science Translational Medicine, 10(446), eaao2565. (doi: 10.1126/scitranslmed.aao2565) (PMID:29925636)


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