Daniel M Davis

Daniel M Davis first obtained a doctoral degree in Physics in Glasgow, UK, before he studied the immune system at Harvard University. At the moment, he is a professor of Immunology at Manchester University and Director of Research in the Manchester Collaborative Centre for Inflammation Research. Prof. Davis and his team pioneered the investigation of the immune cells using next-level imaging techniques, which enable them to study the changing arrangement in individual immune cells. The team hypothesize that, the nanometre-scale changes to the immune cell surface organization contributes to the regulation of immune response, and they are studying the relationship between the two in different molecular and physiological contexts. Combing the progressing knowledge of the immune cell mechanisms, Prof. Davis’s team hopes to disclose novel therapeutic approaches regulating the immune responses.

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The University of Manchester

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Immune Responses 0 Membrane Nanotubes 0 Microscopy 0 Immunology 0

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  1. Smith SL, Kennedy PR, Stacey KB, et al. Diversity of peripheral blood human NK cells identified by single-cell RNA sequencing. Blood Adv. 2020;4(7):1388-1406. doi:10.1182/bloodadvances.2019000699

  2. Williamson DJ, Burn GL, Simoncelli S, et al. Machine learning for cluster analysis of localization microscopy data. Nat Commun. 2020;11(1):1493. Published 2020 Mar 20. doi:10.1038/s41467-020-15293-x

  3. Leung EYL, Ennis DP, Kennedy PR, et al. NK Cells Augment Oncolytic Adenovirus Cytotoxicity in Ovarian Cancer. Mol Ther Oncolytics. 2020;16:289-301. Published 2020 Feb 15. doi:10.1016/j.omto.2020.02.001

  4. Kennedy PR, Barthen C, Williamson DJ, et al. Genetic diversity affects the nanoscale membrane organization and signaling of natural killer cell receptors. Sci Signal. 2019;12(612):eaaw9252. Published 2019 Dec 17. doi:10.1126/scisignal.aaw9252

  5. Sowinski S, Jolly C, Berninghausen O, et al. Membrane nanotubes physically connect T cells over long distances presenting a novel route for HIV-1 transmission. Nat Cell Biol. 2008;10(2):211-219. doi:10.1038/ncb1682


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