Cindi M. Morshead

Professor Cindi Morshead did her PhD at the University of Toronto and her thesis identified the neural stem cell niche in the adult brain. She did postdoctoral work that examined the endogenous neural stem cells and their behaviour in response to growth factors and injury, at the University of Toronto. Since 2003, she was appointed as a Professor of the Division of Anatomy at the University of Toronto. Morshead leads her lab in the research on neural stem cells, and the lab is interested in the capacity of stem cells to regenerate injured/diseased tissue, based on the understanding of their fundamental biology. They consider both exogenous cell transplantation paradigms as well as endogenous strategies to activate the resident neural stem and progenitor cells in animal models of injury/disease. In the recent paper, the Morshead Lab recently published a therapeutic delivery method based on hydrogel, which allows a co-delivery of two biomolecules, cyclosporine and erythropoietin that are shown to aid the functional recovery of the brain tissue in rat models.

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University of Toronto

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Stem Cell Biology 0 Neural Repair Strategies 0 Stem Cell Activation Strategies 0 Microscopy 0 Bioengineering 0 Regenerative Medicine 0

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  1. Tuladhar A, Obermeyer JM, Payne SL, et al. Injectable hydrogel enables local and sustained co-delivery to the brain: Two clinically approved biomolecules, cyclosporine and erythropoietin, accelerate functional recovery in rat model of stroke. Biomaterials. 2020;235:119794. doi:10.1016/j.biomaterials.2020.119794

  2. Zhang S, Scott E, Singh J, Chen Y, Zhang Y, Elsayed N, Chamberlain MD, Shakiba N, Adams K, Yu S, Morshead CM, Zandstra PW, Wheeler AR. (2019) The optoelectronic microrobot: A versatile toolbox for micromanipulation. PNAS. July 9.

  3. Morrison TJ, Sefton E, Marquez-Chin M, Popovic MR, Morshead CM, Naguib HE. (2019) A 3D-printed device for low-cost stimulation in mice. Frontiers in Neuroscience. doi:10.3389/fnins.2019.00784.

  4. Ruddy RM, Adams KV, Morshead CM. Age- and sex-dependent effects of metformin on neural precursor cells and cognitive recovery in a model of neonatal stroke. Sci Adv. 2019;5(9):eaax1912. Published 2019 Sep 11. doi:10.1126/sciadv.aax1912

  5. Zhang S, Scott EY, Singh J, et al. The optoelectronic microrobot: A versatile toolbox for micromanipulation. Proc Natl Acad Sci U S A. 2019;116(30):14823-14828. doi:10.1073/pnas.1903406116


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