Christopher P. Hill

Christopher Hill, D.Phil., Vice Dean of Research for the School of Medicine, he is a distinguished professor in the Department of Biochemistry at the University of Utah School of Medicine. holds the H.A. and Edna Benning Medical Society Chair, and is a member of the Nuclear Control of Cell Growth and Differentiation Program. Hill received his BA and D.Phil. from the University of York, England. He then completed a postdoctoral fellowship at the University of California at Los Angles. Hill presents and publishes widely and has received numerous research fellowships and grants. The Hill Lab uses structural and biochemical approaches to study how proteins function. This approach is applied to numerous targets that are relevant to cancer mechanisms. Studies on proteasome and protein quality control seek to understand mechanisms in a validated cancer therapeutic target. Studies of HIV-host interactions and the ESCRT pathway have led into mechanistic studies on how cells divide, and may inform new approaches to prevent the uncontrolled proliferation characteristic of cancers. Studies on nucleosome remodeling and reorganizing complexes advance understanding of mechanisms of gene expression, which may offer insights to the genetic defects that underlie progression toward cancer.

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The University of Utah

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Structural Biology 0 Proteasome Activation and Regulation 0 HIV Structure and Host Interactions 0 ESCRT Pathway 0 Nucleosome Remodeling and Reorganization 0

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  1. Tsai FTF, Hill CP. Same structure, different mechanisms?. Elife. 2020;9:e56501. Published 2020 Apr 23. doi:10.7554/eLife.56501

  2. Xiong X, Blakely A, Karra P, et al. Novel four-disulfide insulin analog with high aggregation stability and potency. Chem Sci. 2019;11(1):195-200. Published 2019 Nov 5. doi:10.1039/c9sc04555d

  3. Han H, Schubert HL, McCullough J, et al. Structure of spastin bound to a glutamate-rich peptide implies a hand-over-hand mechanism of substrate translocation. J Biol Chem. 2020;295(2):435-443. doi:10.1074/jbc.AC119.009890

  4. Smith AR, Weinstock MT, Siglin AE, et al. Characterization of resistance to a potent D-peptide HIV entry inhibitor. Retrovirology. 2019;16(1):28. Published 2019 Oct 22. doi:10.1186/s12977-019-0489-7

  5. Cooney I, Han H, Stewart MG, et al. Structure of the Cdc48 segregase in the act of unfolding an authentic substrate. Science. 2019;365(6452):502-505. doi:10.1126/science.aax0486

  6. Han H, Fulcher JM, Dandey VP, et al. Structure of Vps4 with circular peptides and implications for translocation of two polypeptide chains by AAA+ ATPases. Elife. 2019;8:e44071. Published 2019 Jun 11. doi:10.7554/eLife.44071


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