Bebhinn Treanor

Dr. Bebhinn Treanor completed her PhD at Imperial College London under the supervision of Dr. Daniel M. Davis in 2006, where she visualized the spatial confinement of phosphorylated NK cell inhibitory receptors to ‘hotspots’, providing a new framework for understanding how NK cells integrate activating and inhibitory signals. She then went on to complete her postdoctoral work in the laboratory of Dr. Facundo Batista at the London Research Institute of Cancer Research UK, where she identified that the cortical actin cytoskeleton plays a critical role in controlling B cell receptor signaling. Her research focuses on the cellular and molecular mechanisms of immune cell activation. Regarding the critical role of the cell surface receptors involved in the immune responses, Dr. Treanor’s lab investigates the molecular mechanisms that control that organization and activity of the cell surface receptors. An example of her research is the glycan-based domains generated by the binding of galectins to cell surface glycoproteins; Dr. Treanor’s team employs advanced optical microscopy techniques to explore how these cell-surface scaffolding proteins could modulate the interaction, function and turnover of immune cell glycoproteins.

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University of Toronto

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B Cells 0 Immune Cells 0 Cell Surface Receptors 0 Immune Responses 0 Microscopy 0 Cell Signaling 0 Molecular Biology 0

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  1. Huang L, Sun X, Yang D, et al. WASP and Mst1 coregulate B-cell development and B-cell receptor signaling. Blood Adv. 2020;4(3):573-585. doi:10.1182/bloodadvances.2018027870

  2. Aguilar OA, Sampaio IS, Rahim MMA, et al. Mouse Cytomegalovirus m153 Protein Stabilizes Expression of the Inhibitory NKR-P1B Ligand Clr-b. J Virol. 2019;94(1):e01220-19. Published 2019 Dec 12. doi:10.1128/JVI.01220-19

  3. Mahtani T, Treanor B. Beyond the CRAC: Diversification of ion signaling in B cells. Immunol Rev. 2019;291(1):104-122. doi:10.1111/imr.12770

  4. Wasim L, Buhari FHM, Yoganathan M, et al. N-Linked Glycosylation Regulates CD22 Organization and Function. Front Immunol. 2019;10:699. Published 2019 Apr 4. doi:10.3389/fimmu.2019.00699

  5. Giovannone N, Smith LK, Treanor B, Dimitroff CJ. Galectin-Glycan Interactions as Regulators of B Cell Immunity. Front Immunol. 2018;9:2839. Published 2018 Dec 4. doi:10.3389/fimmu.2018.02839

  6. Cao A, Alluqmani N, Buhari FHM, et al. Galectin-9 binds IgM-BCR to regulate B cell signaling. Nat Commun. 2018;9(1):3288. Published 2018 Aug 17. doi:10.1038/s41467-018-05771-8


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