Beate Escher

Beate Escher’s research interest focus on mode-of-action based environmental risk assessment, including methods for initial hazard screening and risk assessment of pharmaceuticals, pesticides, disinfection by-products and persistent organic pollutants with an emphasis on mixtures. A special interest is the effect assessment of transformation products and disinfection by-products. One of Escher’s goals is to close the gap between exposure and effect assessment through common approaches linking bioavailability to internal exposure and effects via understanding and modelling of toxicokinetic and toxicodynamic processes. More practically oriented aspects of her work include passive sampling and effect-based methods for water quality assessment. Further she has an interest in improving dosing methods for very hydrophobic and volatile compounds and to develop new in-vitro assays for bioaccumulation and toxicity assessment.

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Helmholtz Centre for Environmental Research–UFZ

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Mode-of-action based environmental risk assessment 0 Water Quality Assessment 0 Toxicokinetic and Toxicodynamic Processes 0

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  1. Escher BI, Henneberger L, König M, Schlichting R, Fischer FC. Cytotoxicity Burst? Differentiating Specific from Nonspecific Effects in Tox21 in VitroReporter Gene Assays. Environ Health Perspect. 2020;128(7):77007. doi:10.1289/EHP6664

  2. Neale PA, Braun G, Brack W, et al. Assessing the Mixture Effects in In Vitro Bioassays of Chemicals Occurring in Small Agricultural Streams during Rain Events. Environ Sci Technol. 2020;54(13):8280-8290. doi:10.1021/acs.est.0c02235

  3. Huchthausen J, Mühlenbrink M, König M, Escher BI, Henneberger L. Experimental Exposure Assessment of Ionizable Organic Chemicals in In Vitro Cell-Based Bioassays. Chem Res Toxicol. 2020;33(7):1845-1854. doi:10.1021/acs.chemrestox.0c00067

  4. Müller ME, Werneburg M, Glaser C, et al. Influence of Emission Sources and Tributaries on the Spatial and Temporal Patterns of Micropollutant Mixtures and Associated Effects in a Small River. Environ Toxicol Chem. 2020;39(7):1382-1391. doi:10.1002/etc.4726

  5. Fischer FC, Abele C, Henneberger L, et al. Cellular Metabolism in High-Throughput In Vitro Reporter Gene Assays and Implications for the Quantitative In Vitro-In VivoExtrapolation. Chem Res Toxicol. 2020;33(7):1770-1779. doi:10.1021/acs.chemrestox.0c00037


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