Bazbek Davletov

Bazbek Davletov completed his Ph.D. in the lab of Nobel Prize winner Prof Thomas Sudhof, at the University of Texas Southwestern Medical Center, Dallas, USA. He has been a Programme Leader at the MRC Laboratory of Molecular Biology at Cambridge since 1998, before becoming the Chair of Biomedical Science and Professor at the University of Sheffield. Prof Davletov’s lab pursue the research of neurological disorders including chronic neuropathic pain, with a focus of developing enhanced delivery methods. Their work encompasses the study of mechanisms of action of potent neurotoxins and molecular mechanisms of neurotransmission, and, based of which, they are able to test and utilise potential therapeutic molecules, for example, SNAP25, and botulinum for the selective treatment of chronic pain. Complementarily, Davletov and his group also designed a delivery technique, “Protein Stapling”, which allows the conjugation of an effector molecule such as a therapeutic engineered botulinum neurotoxin to the target neuron or agent. In addition, the protein stapling method is extended to the design of new multifunctional cancer therapies.

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Davletov Lab, Department of Biomedical Science, University of Sheffield

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Neurotoxins 0 Neurotransmission 0 Chronic Pain 0 Therapies for Neurological Disorders and Cancer 0 Molecular Engineering 0

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  1. Leese C, Bresnahan R, Doran C, et al. Duplication of clostridial binding domains for enhanced macromolecular delivery into neurons. Toxicon X. 2020;5:100019. doi:10.1016/j.toxcx.2019.100019

  2. Gimenez-Molina Y, García-Martínez V, Villanueva J, Davletov B, Gutiérrez LM. Multiple sclerosis drug FTY-720 toxicity is mediated by the heterotypic fusion of organelles in neuroendocrine cells. Sci Rep. 2019;9(1):18471. Published 2019 Dec 5. doi:10.1038/s41598-019-55106-w

  3. Maiarù M, Leese C, Certo M, et al. Selective neuronal silencing using synthetic botulinum molecules alleviates chronic pain in mice. Sci Transl Med. 2018;10(450):eaar7384. doi:10.1126/scitranslmed.aar7384

  4. Rust A, Shah S, Hautbergue GM, Davletov B. Burkholderia Lethal Factor 1, a Novel Anti-Cancer Toxin, Demonstrates Selective Cytotoxicity in MYCN-Amplified Neuroblastoma Cells. Toxins (Basel). 2018;10(7):261. Published 2018 Jun 27. doi:10.3390/toxins10070261

  5. Darios FD, Jorgacevski J, Flašker A, et al. Sphingomimetic multiple sclerosis drug FTY720 activates vesicular synaptobrevin and augments neuroendocrine secretion. Sci Rep. 2017;7(1):5958. Published 2017 Jul 20. doi:10.1038/s41598-017-05948-z

  6. Mohrmann R, de Wit H, Connell E, et al. Synaptotagmin interaction with SNAP-25 governs vesicle docking, priming, and fusion triggering. J Neurosci. 2013;33(36):14417-14430. doi:10.1523/JNEUROSCI.1236-13.2013


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