Bastiaan T. Heijmans

The research of Heijmans’ group focuses on the discovery of epigenomic signatures of genetic and environmental influences that affect cardiometabolic disease and ageing in humans. To this end, they perform genome scale analyses of population studies, including (monochorionic) twins, long-lived families and individuals who were exposed to the Dutch Famine at the end of WW2. To maximize biological insight from these studies, they develop methodology and tools, integrate epigenomics data with interconnected –omics layers (e.g. genome and transcriptome), address the biological role of DNA methylation, and apply in vitro models to uncover causal epigenomic mechanisms. The long-term perspective of the group is to spur on the development personalized medicine.

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Leiden University Medical Center

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Population Epigemoics 0 Integrative genomics 0 DNA Methylation 0 Aging 0 Personal Medicine 0

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  1. Tilburg J, Slieker RC, Suchiman HED, et al. Repeat UVA exposure of human skin fibroblasts induces both a transitionary and recovery DNA methylation response. Epigenomics. 2020;12(7):563-573. doi:10.2217/epi-2019-0251

  2. Herzog EM, Eggink AJ, Willemsen SP, et al. The tissue-specific aspect of genome-wide DNA methylation in newborn and placental tissues: implications for epigenetic epidemiologic studies [published online ahead of print, 2020 Apr 24]. J Dev Orig Health Dis. 2020;1-11. doi:10.1017/S2040174420000136

  3. Salgado C, Gruis N; BIOS Consortium, Heijmans BT, Oosting J, van Doorn R. Genome-wide analysis of constitutional DNA methylation in familial melanoma. Clin Epigenetics. 2020;12(1):43. Published 2020 Mar 6. doi:10.1186/s13148-020-00831-7

  4. Bonder MJ, Luijk R, Zhernakova DV, et al. Disease variants alter transcription factor levels and methylation of their binding sites. Nat Genet. 2017;49(1):131-138. doi:10.1038/ng.3721

  5. Wahl S, Drong A, Lehne B, et al. Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity. Nature. 2017;541(7635):81-86. doi:10.1038/nature20784

  6. Bell CG, Lowe R, Adams PD, et al. DNA methylation aging clocks: challenges and recommendations. Genome Biol. 2019;20(1):249. Published 2019 Nov 25. doi:10.1186/s13059-019-1824-y


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