Ari Sadanandom

Professor Ari Sadanandom is a plant scientist at Durham University. His research centred on the plant ubiquitin-proteasome system (UPS), which is a central modifier of signalling in animals and plants, and is often a target of the pathogen induced signalling to suppress the host immunity. Using Arabidopsis, tobacco and tomato as model hosts, Prof Sadanandom’s laboratory employs a cross disciplinary approach including genetic, molecular and biochemical techniques to identify components that are specifically ubiquitinated by bacterial and fungal pathogens to undermine plant immunity. In addition, combining the interest in another class of ubiquitin-related polypeptide tags called small ubiquitin-like modifiers (SUMO) (specific signalling proteins are SUMOylated as part of plant survival strategy during drought, heat and high salinity), the Sadanandom group aims to understand the protein modification regulatory mechanisms in plants, which may provide useful knowledge for fostering pathogen and stress resistant crops.

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Durham University

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Plant Ubiquitin-Proteasome System 0 Plant Stress Response 0 Small Ubiquitin-like Modifiers (SUMO) 0 Protein Modification Regulation 0

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  1. Srivastava, Moumita, Srivastava, Anjil K., Orosa-Puente, Beatriz, Campanaro, Alberto, Zhang, Cunjin & Sadanandom, Ari (2020). SUMO Conjugation to BZR1 Enables Brassinosteroid Signaling to Integrate Environmental Cues to Shape Plant Growth. Current Biology 30(8): 1410-1423.e3.

  2. Morrell, Rebecca & Sadanandom, Ari (2019). Dealing With Stress: A Review of Plant SUMO Proteases. Frontiers in Plant Science 10: 1122.

  3. Aliaga-Franco, Norma, Zhang, Cunjin, Presa, Silvia, Srivastava, Anjil K., Granell, Antonio, Alabadí, David, Sadanandom, Ari, Blázquez, Miguel A. & Minguet, Eugenio G. (2019). Identification of Transgene-Free CRISPR-Edited Plants of Rice, Tomato, and Arabidopsis by Monitoring DsRED Fluorescence in Dry Seeds. Frontiers in Plant Science 10: 1150.

  4. Verma, Vivek, Croley, Fenella & Sadanandom, Ari (2018). Fifty shades of SUMO: its role in immunity and at the fulcrum of the growth-defence balance. Molecular Plant Pathology 19(6): 1537.

  5. De Vega, Daniel, Newton, Adrian C. & Sadanandom, Ari (2018). Post-translational modifications in priming the plant immune system: ripe for exploitation?. FEBS Letters 592(12): 1929-1936.

  6. Castro, Pedro Humberto, Bachmair, Andreas, Bejarano, Eduardo R, Coupland, George, Lois, L Maria, Sadanandom, Ari, van den Burg, Harrold A, Vierstra, Richard D & Azevedo, Herlander (2018). Revised nomenclature and functional overview of the ULP gene family of plant deSUMOylating proteases. Journal of Experimental Botany 69(19): 4505-4509.


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