Ardem Patapoutian

Dr. Ardem Potapoutian is a molecular biologist specializing in sensory transduction. He obtained his PhD in Biology at California Institute of Technology in 1996, and did postdoctoral training at the University of California at San Francisco in Louis Reichardt’s lab. Dr. Potapoutian is currently a Professor at Scripps Research Institute, and an Investigator of the Howard Hughes Medical Institute. The research of Dr. Potapoutian specialized in the identification and characterization of ion channels and other sensors that translate mechanical stimuli to chemical signals. The Patapoutian Lab has contributed a lot to our understanding of mechanotransduction and the functions of the ion channels in the sensory process to touch/pain (somatosensation), sound (hearing), sheer stress (cardiovascular tone), and more, by the discovery of novel ion channels, for instance, Piezo1 and Piezo2, which are mechanically-activated cation channels expressed in many mechanosensitive cell types. They recently co-discovered SWELL1 (LRRC8A), an essential component of the volume-regulated ion channel (VRAC) for maintaining cell volume in response to osmotic challenge. They also identified GPR68, a G protein-coupled receptor, as a novel mechanosensor for blood flow.

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Dorris Neuroscience Center, The Scripps Research Institute

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Sensory Ion Channels 0 Mechanotransduction 0 Polymodal Chemosensors 0 Piezo1 and Piezo2 Mechanosensors 0

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  1. Marshall K, Patapoutian A. Getting a grip on touch receptors. Science. 2020;368(6497):1311-1312. doi:10.1126/science.abc7610

  2. Nonomura K, Lukacs V, Sweet DT, et al. Mechanically activated ion channel PIEZO1 is required for lymphatic valve formation. Proc Natl Acad Sci U S A. 2018;115(50):12817-12822. doi:10.1073/pnas.1817070115

  3. Zeng WZ, Marshall KL, Min S, et al. PIEZOs mediate neuronal sensing of blood pressure and the baroreceptor reflex. Science. 2018;362(6413):464-467. doi:10.1126/science.aau6324

  4. Murthy SE, Loud MC, Daou I, et al. The mechanosensitive ion channel Piezo2 mediates sensitivity to mechanical pain in mice. Sci Transl Med. 2018;10(462):eaat9897. doi:10.1126/scitranslmed.aat9897

  5. Xu J, Mathur J, Vessières E, et al. GPR68 Senses Flow and Is Essential for Vascular Physiology. Cell. 2018;173(3):762-775.e16. doi:10.1016/j.cell.2018.03.076


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