Anthony George

Assoc Prof Anthony George obtained his PhD degree from the University of Sydney in 1981, and he finished postdoctoral study at Tufts University Medical School (Boston) and the John Curtin School of Medical Research (Canberra). In 1986, he was tenured at UTS with academic position, where he continued his early research in the field of pathogenic bacteria, which recently transferred to pathogenic infections in severe medical syndromes like cystic fibrosis. Now George is researching mainly in two topics, with the first one centered on a protein family called ABC transporters, to which MDR protein belongs. His team has been very successful in this field, as they discovered the dimeric structural configuration of ABC transporters and elaborated a new model for the function of these proteins. Starting from 2007, George started to investigate treatment to ameliorating the asbestos-related diseases what were considered incurable. Through progressive understanding of the counteracting agents in human lung cells towards the impact of asbestos, George’s team has demonstrated the success of the slowing or prevention of the disease (mesothelioma) onset in the mouse model, and they are expecting the first human trial.

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School of Life Science, University of Technology Sydney

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Multidrug Resistance in Pathogenic Bacteria 0 Cystic Fibrosis 0 ABC Transporters 0 Mesothelioma 0 Asbestos-related Disease 0

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  1. Jones, PM, Mazzio, E, Soliman, K & George, AM 2019, 'In Silico Investigation of the Binding of MCoTI-II Plant Defense Knottin to the gamma-NGF Serine Protease of the 7S Nerve Growth Factor Complex and Biological Activity of Its NGF Mimetic Properties', JOURNAL OF PHYSICAL CHEMISTRY B, vol. 123, no. 43, pp. 9104-9110

  2. Fan, X, McLaughlin, C, Ravasini, J, Robinson, C & George, AM 2018, 'Zeolite protects mice from iron-induced damage in a mouse model trial', FEBS Open Bio, vol. 8, no. 11, pp. 1773-1781.

  3. Cheng, YY, Mok, E, Tan, S, Leygo, C, McLaughlin, C, George, AM & Reid, G 2017, 'SFRP Tumour Suppressor Genes Are Potential Plasma-Based Epigenetic Biomarkers for Malignant Pleural Mesothelioma.', Disease Markers, vol. 2017, pp. 1-11.

  4. Jones, PM & George, AM 2017, 'How Intrinsic Dynamics Mediates the Allosteric Mechanism in the ABC Transporter Nucleotide Binding Domain Dimer.', Journal of Chemical Theory and Computation, vol. 13, no. 4, pp. 1712-1722.

  5. Mittra, R, Pavy, M, Subramanian, N, George, AM, O'Mara, ML, Kerr, ID & Callaghan, R 2017, 'Location of contact residues in pharmacologically distinct drug binding sites on P-glycoprotein.', Biochemical Pharmacology, vol. 123, pp. 19-28.


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