Anna Williams

Prof Anna Williams is named the personal chair of Regenerative Medicine as a research group leader at the University of Edinburgh. The focus of group is the recover myelination processes in the context of brain damages resulted from diseases like multiple sclerosis (MS), as even though remyelination may occur it will be however insufficient to fully restore the brain function. They are investigating how this injury happens, why it fails in MS, and how is it restored with the aim of trying to make the repair process more efficient. They use in vitro and ex vivo cultures of rodents and use human ES derived cells, human post mortem tissue and in vivo rodent and zebrafish models. We manipulate levels of molecules of interest with recombinant proteins, lentiviral transduction and using transgenic animals. In a recent paper they applied CRISPR/Cas9 to facilitate the reprogramming of fibroblasts to oligodendrocyte progenitor-like cells (Matjusaitis et al., 2019). William’s group is particularly interested in molecules that control recruitment of oligodendrocyte precursor cells into demyelinated lesions, and is currently investigating small molecule inhibitors of chemorepulsive factors for OPCs.

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Edinburgh Neuroscience

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Neuron Remyelination 0 Multiple Sclerosis 0 Oligodendrocyte Precursor Cells 0 Stem Cells 0 Genetic Engineering 0 Neuroregenerative Medicine 0

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  1. Lubetzki C, Zalc B, Williams A, Stadelmann C, Stankoff B. Remyelination in multiple sclerosis: from basic science to clinical translation. Lancet Neurol. 2020;19(8):678-688. doi:10.1016/S1474-4422(20)30140-X

  2. Macchi M, Magalon K, Zimmer C, et al. Mature oligodendrocytes bordering lesions limit demyelination and favor myelin repair via heparan sulfate production. Elife. 2020;9:e51735. Published 2020 Jun 9. doi:10.7554/eLife.51735

  3. Moss J, Williams A. Opening the floodgates to the brain. Science. 2020;367(6483):1195-1196. doi:10.1126/science.aba8801

  4. Matjusaitis M, Wagstaff LJ, Martella A, et al. Reprogramming of Fibroblasts to Oligodendrocyte Progenitor-like Cells Using CRISPR/Cas9-Based Synthetic Transcription Factors. Stem Cell Reports. 2019;13(6):1053-1067. doi:10.1016/j.stemcr.2019.10.010

  5. Lloyd AF, Davies CL, Holloway RK, et al. Central nervous system regeneration is driven by microglia necroptosis and repopulation. Nat Neurosci. 2019;22(7):1046-1052. doi:10.1038/s41593-019-0418-z


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