Andrew Pitsillides

Professor Andrew Pitsillides obtained Ph.D. in Biochemistry at the Kennedy Institute of Rheumatology. Andrew's work covers many inter-related themes in skeletal biology focussed on bone and joint mechanobiology. His group’s in vitro studies described how limb movements might directly influence cell behaviour to achieve joint cavitation, essential for articulation, establishing key roles for ERK/p38 kinases and factors otherwise 'classically' linked to inflammatory pathways. His group are now exploring how mechanobiology may regulate endochondral ossification processes, with a specific focus on identifying key targets for translation. Work in his group also aims to define how developing and adult bone adapts to functional use. His work found that nitric oxide production was an early obligatory step in such mechanomodulation, with a genetic component linked to growth rate. His work also contributed to defining important differences between how osteocytes and osteoblasts might contribute to bone mechanoadaptive responses and how these fail in osteoporosis. His group have recently developed an elegant in vivo model for addressing these questions by controlled in vivo bone loading and is using state-of-the-art imaging to explore how bone shape and mass are biomechanically matched to function.

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The Royal Veterinary College

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Skeletal Mechanobiology 0 Endochondral Ossification Processes 0 Mechanomodulation 0 Genetics 0

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  1. Javaheri B, Carriero A, Wood M, De Souza R, Lee PD, Shefelbine S, Pitsillides AA. (2018) Transient peak-strain matching partially recovers the age-impaired mechanoadaptive cortical bone response. Scientific Reports. 8(1):6636. doi: 10.1038/s41598-018-25084-6.

  2. Novicky A, Caetano-Silva SP, Javaheri B, Pitsillides AA. (2018) Chapter 2: The Mechanics of Skeletal Development. In: Developmental Biology and Musculoskeletal Tissue Engineering - 1st Edition. Elsevier Press. ISBN 9780128114674

  3. Núñez JA, Goring A, Javaheri B, Gomez-Nicola D, Hesse E, Pitsillides AA, Schneider P, Thurner PJ and Clarkin CE. (2018). Regional diversity in the murine cortical vascular network is revealed by synchrotron X-ray tomography and is amplified with age. European Cell and Materials. 35:281-299. doi: 10.22203/eCM.v035a20.

  4. Javaheri B, Razi H, Piles M, de Souza R, Chang Y-M, Maric-Mur I, Hopkinson M, Lee PD, Pitsillides AA. (2018) Sexually dimorphic tibia shape is linked to natural osteoarthritis in STR/Ort mice. Osteoarthritis Cartilage S1063-4584(18)31129-4. doi: 10.1016/j.joca.2018.03.008

  5. Ramos-Mucci L, Javaheri B, van 't Hof R, et al. (2020) Meniscal and ligament modifications in spontaneous and post-traumatic mouse models of osteoarthritis. Arthritis Res Ther. 2020;22(1):171. Published 2020 Jul 16. doi:10.1186/s13075-020-02261-5


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