Andrés García

Dr. Andrés J. García is Principal Investigator at Georgia Tech, he is also named Executive Director of Parker H. Petit Institute for Bioengineering & Bioscience, The Petit Director's Chair in Bioengineering and Bioscience, and Regents' Professor at George Woodruff School of Mechanical Engineering. Dr. García's research centers on cellular and tissue engineering, areas which integrate engineering and biological principles to control cell function in order to restore and/or enhance function in injured or diseased organs. Specifically, his research focuses on fundamental structure-function relationships governing cell-biomaterials interactions for bone and muscle applications. Current projects of Dr. García's lab involve the analysis and manipulation of cell adhesion receptors and their extracellular matrix ligands. For example, a mechanochemical system has been developed to analyze the contributions of receptor binding, clustering, and interactions with other cellular structural proteins to cell adhesion strength. In another research thrust, bio-inspired surfaces, including micropatterned substrates, are engineered to control cell adhesion in order to direct signaling and cell function. For instance, biomolecular surfaces have been engineered to target specific adhesion receptors to modulate cell signaling and differentiation. These biomolecular strategies are applicable to the development of 3D hybrid scaffolds for enhanced tissue reconstruction,"smart" biomaterials, and cell growth supports. The lab applies genetic engineering approaches to engineer cells that form bone tissue for use in the development of mineralized templates for enhanced bone repair.

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Cell Adhesion Receptors 0 Cell-biomaterial Interaction 0 Regenerative Medicine 0 Novel Biomaterials 0 Genetic Engineering 0

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  3. Xu J, Jia YF, Tapadar S, et al. Inhibition of TBK1/IKKε Promotes Regeneration of Pancreatic β-cells [published correction appears in Sci Rep. 2019 Dec 3;9(1):18570]. Sci Rep. 2018;8(1):15587. Published 2018 Oct 22. doi:10.1038/s41598-018-33875-0

  4. Cruz-Acuña R, Quirós M, Huang S, et al. PEG-4MAL hydrogels for human organoid generation, culture, and in vivo delivery [published correction appears in Nat Protoc. 2018 Oct 24;:]. Nat Protoc. 2018;13(9):2102-2119. doi:10.1038/s41596-018-0036-3

  5. Phelps EA, Enemchukwu NO, Fiore VF, Sy JC, Murthy N, Sulchek TA, Barker TH, García AJ. Maleimide Cross-linked bioactive PEG hydrogel exhibits improved reaction kinetics and cross-linking for cell encapsulation and in situ delivery. Advanced Materials. 2012; 24:64-70.


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