Alexandre Prat

Prof. Alexandre Prat completed his PhD study on human Blood-Brain Barrier (BBB) at McGill University, in 2000, before receiving Neurology residency training there. Prat is now a Full Professor of Neuroscience at Université de Montréal, where he carried on his previous research interest. Currently, Prat’s group is studying the immunological roles of the BBB, the mechanisms of monocytes and lymphocyte migration across the BBB and the physiological regulation of the Blood-Brain Barrier functions by glial cells. The underlying hypothesis of Prat’s work is that deciphering the mechanisms by which the Blood-Brain Barrier controls the passage of cells and molecules to the CNS should lead to the understanding of diseases such as Multiple sclerosis and brain tumors, as well as to the discovery of novel routes for delivery of drugs and chemotherapies into the CNS. The Prat lab’s research emphasizes on the biology of human and mouse TH1 and TH17 lymphocytes, which has led to the identification of TH17 lymphocytes’ essential link to the pathogenesis of numerous inflammatory diseases, by the lab.

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University of Montreal Hospital Research Centre

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Immunology 0 Blood-Brain Barrier 0 Multiple Sclerosis 0 Autoimmune Diseases 0 Th1, Th2 and Th17 lymphocytes 0 CD4 and CD8 T lymphocyte 0 Microscopy and Cytometry 0

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  1. Wheeler, M.A., Clark, I.C., Tjon, E.C. et al. Nature 578, 593–599 (2020). https://doi.org/10.1038/s41586-020-1999-0

  2. Takenaka, M.C., Gabriely, G., Rothhammer, V. et al. Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39. Nat Neurosci 22, 729–740 (2019). https://doi.org/10.1038/s41593-019-0370-y

  3. Rothhammer V, Mascanfroni ID, Bunse L, Takenaka MC, Kenison JE, Mayo L, Chao CC, Patel B, Yan R, Blain M, Alvarez JI, Kébir H, Anandasabapathy N, Izquierdo G, Jung S, Obholzer N, Pochet N , Clish CB, Prinz M, Prat A , Antel J, Quintana FJ. (2016) Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor. Nat Med, May 9. 22 (6): 586-97. doi: 10.1038 / nm.4106

  4. Larochelle C, Lecuyer MA, Alvarez JI, Charabati M, Saint-Laurent O, Kébir H, Flanagan K, Yednock T, Duquette P, Arbor N and Prat A. (2015) MCAM + CD8 T lymphocytes mediate CNS inflammation. Ann. Neurol , Jul; 78 (1) 39-53;

  5. Kebir, H., Kreymborg, K., Ifergan, I. et al. Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation. Nat Med 13, 1173–1175 (2007). https://doi.org/10.1038/nm1651


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