Alexander Ploss

Dr. Alexander Ploss is an Associated Professor of Molecular Biology at Princeton University. Research of his lab focuses on immune responses and pathogenesis to human pathogens infecting the liver, including hepatitis B (HBV) and C viruses (HCV), yellow fever and Dengue viruses and plasmodial parasites. Dr. Ploss’ group combines tissue engineering, molecular virology/pathogenesis, and animal construction, to create and apply innovative technologies for the study and intervention of human hepatotropic infections. In particular, the Ploss Lab is exploiting the generation of “humanized mice”, which are amenable small animal models transplanted with human cells or tissues (and/or equipped with human transgenes) that may be ideally suited for direct investigation of human infectious agents; such systems offer unprecedented opportunities to effectively study host-pathogen interactions in vivo and to preclinically evaluate drug and vaccine candidates, where they are already recruited in the parallel research in the Ploss Lab, for instance, the study of molecular features of P. vivax and P. cynomolgi.

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Princeton University

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Pathogenesis of Viral Hepatitis 0 Determinants of Interspecies Tropism of Human Hepatotropic Pathogens 0 Molecular Characterization of Plasmodial Dormancy 0 Human-mouse Chimera For the Study of Human Infectious Disease 0

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  1. Berggren KA, Suzuki S, Ploss A. Animal Models Used in Hepatitis C Virus Research. Int J Mol Sci. 2020;21(11):3869. Published 2020 May 29. doi:10.3390/ijms21113869

  2. Ramanathan HN, Zhang S, Douam F, et al. A Sensitive Yellow Fever Virus Entry Reporter Identifies Valosin-Containing Protein (VCP/p97) as an Essential Host Factor for Flavivirus Uncoating. mBio. 2020;11(2):e00467-20. Published 2020 Apr 14. doi:10.1128/mBio.00467-20

  3. Wei L, Ploss A. Core components of DNA lagging strand synthesis machinery are essential for hepatitis B virus cccDNA formation. Nat Microbiol. 2020;5(5):715-726. doi:10.1038/s41564-020-0678-0

  4. Chen CY, Winer BY, Chavez D, et al. Woolly Monkey-HBV Infection in Squirrel Monkeys as a Surrogate Nonhuman Primate Model of HBV Infection. Hepatol Commun. 2020;4(3):371-386. Published 2020 Jan 3. doi:10.1002/hep4.1471

  5. Winer BY, Gaska JM, Lipkowitz G, et al. Analysis of Host Responses to Hepatitis B and Delta Viral Infections in a Micro-scalable Hepatic Co-culture System. Hepatology. 2020;71(1):14-30. doi:10.1002/hep.30815


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