Aleksandra Filipovska

Prof. Aleksandra Filipovska completed her PhD study at the University of Otago, New Zealand in 2002 and from 2003-2005 she was a NZ Foundation for Research, Science and Technology Fellow at the MRC Mitochondrial Biology Unit in Cambridge, the United Kingdom. She relocated to Australia as a NHMRC Howard Florey Fellow and formed her research group at the Harry Perkins Institute; she is currently a Research Professor at the University of Western Australia. Prof. Aleksandra’s lab is interested in the gene expression in mitochondria regulated by RNA-binding proteins, meanwhile the pathogenicity of genetic mutations in the mitochondrial or nuclear genome, which encode proteins or regulatory RNAs responsible for mitochondrial biogenesis. Her lab uses synthetic biology and genome editing tools to create unique and physiologically relevant models of human diseases caused by impaired gene expression, thereby utilizing the models to identify how changes in the mitochondrial and nuclear genomes cause mitochondrial dysfunction in neurological, cardiovascular and metabolic disease, in cancer and in ageing. They aim to identify targets and develop corresponding to provide potential treatments for these diseases and improve energy function.

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Harry Perkins Institute of Medical Research

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  1. Liu, G., Mercer, T.R., Shearwood, A.-M.J., Siira, S.J., Hibbs, M.E., Mattick, J.S., Rackham, O. and Filipovska, A. (2013) Mapping of mitochondrial RNA-protein interactions by digital RNase footprinting. Cell Reports 5(3):839-48.

  2. Richman, T.R., Ermer, J.A., Davies, S.M., Perks, K.L., Viola, H.M., Shearwood, A.-M.J., Hool, L.C., Rackham, O. and Filipovska, A. (2015) Mutation in MRPS34 compromises protein synthesis and causes mitochondrial dysfunction. PLOS Genetics10.1371/journal.pgen.1005089.

  3. Small, I.D., Rackham O. and Filipovska, A. (2013) Organelle transcriptomes: innovations on a prokaryotic blueprint. Current Opinions in Microbiology 16(5):652-8.

  4. Coquille, S. *, Filipovska, A.*, Chia, T., Rajappa, L., Lingford, J.P., Razif, M.F., Thore, S. and Rackham, O. (2015) An artificial PPR scaffold for programmable RNA recognition. Nature Communications 5:5729. doi: 10.1038/ncomms6729.

  5. Richman, T.R., Davies, S.M.K., Shearwood, A-M.J., Ermer, J.A., Scott, L.H., Hibbs, M.E., Rackham, O. and Filipovska, A. (2014) A bifunctional protein regulates mitochondrial protein synthesis. Nucleic Acids Research 42(9): 5483-94.


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