Aiwu Dong

Aiwu Dong received her Ph.D. degree in Biochemistry from Fudan University in 2003, where she is a Full Professor and serves as the chair of Department of Biochemistry and the head of Institute of Plant Biology. Prof Dong’s research shows a particular interest in the area of plant Epigenetics, and her lab has a long standing interest in key proteins involved in chromatin assembly and histone modification such as nucleosome assembly proteins, chromatin remodeling factors and histone methyltransferases. They use approaches of biochemistry, molecular biology, genetics, structure biology and bioinformatics to understand the molecular mechanisms on how these epigenetic regulators function in the dynamic change of chromatin, cell division and differentiation, and in plant growth and development. Latest research in the Dong Lab centred on epigenetic regulators, for instance histone H3 lysine 36 (H3K36), the methylation of which plays critical roles in brassinosteroid (BR)-related processes and is involved in controlling flowering time in rice (Oryza sativa); they in recent paper published in nature communications (Liu B et al., 2019) demonstrated that a regulatory mechanism contributing to H3K36me3 distribution in plants, while in earlier publications they also revealed the reader protein MRG702, which deciphers the H3K36 methylation information set by its methyltransferase SDG725.

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Institute of Plant Biology Fudan University

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Plant Epigenetics 0 Histone Modifications 0 Chromatin Assembly 0 Plant Growth and Development 0 Bioinformatics 0

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  1. Liu B, Liu Y, Wang B, et al. The transcription factor OsSUF4 interacts with SDG725 in promoting H3K36me3 establishment. Nat Commun. 2019;10(1):2999. Published 2019 Jul 5. doi:10.1038/s41467-019-10850-5

  2. Liu Y, Liu K, Yin L, et al. H3K4me2 functions as a repressive epigenetic mark in plants. Epigenetics Chromatin. 2019;12(1):40. Published 2019 Jul 2. doi:10.1186/s13072-019-0285-6

  3. Wei G, Liu K, Shen T, et al. Position-specific intron retention is mediated by the histone methyltransferase SDG725. BMC Biol. 2018;16(1):44. Published 2018 Apr 30. doi:10.1186/s12915-018-0513-8

  4. Zhu Y, Rong L, Luo Q, et al. The Histone Chaperone NRP1 Interacts with WEREWOLF to Activate GLABRA2 in Arabidopsis Root Hair Development. Plant Cell. 2017;29(2):260-276. doi:10.1105/tpc.16.00719

  5. Jin J, Shi J, Liu B, et al. MORF-RELATED GENE702, a Reader Protein of Trimethylated Histone H3 Lysine 4 and Histone H3 Lysine 36, Is Involved in Brassinosteroid-Regulated Growth and Flowering Time Control in Rice. Plant Physiol. 2015;168(4):1275-1285. doi:10.1104/pp.114.255737


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