Due to the affection of the COVID-19 pandemic, lots of research facilities and institutes were locked down for a long time during 2020. Even though, researchers are trying their best to move their projects forward. Surprisingly, 2020 has been an exciting year for genome editing technologies with lots of breakthroughs. In this article, let’s review some of the most impactful advances in genome editing this year.
CRISPR-free mitochondrial base editor
Mitochondrial DNA (mtDNA) is the small circular chromosome found inside mitochondria. These organelles found in cells have often been called the powerhouse of the cell (wikipedia.org). Mutations in mtDNA are associated with a range of human diseases. However, precise editing to mitochondrial genomes has been hindered by the challenge of transporting RNAs into mitochondria, including guide RNAs that are required for CRISPR-associated proteins.