New Paper Online! "A natural single-guide RNA repurposes Cas9 to autoregulate CRISPR-Cas expression" by researchers from the Department of Molecular Biology & Genetics, Johns Hopkins University School of Medicine. DOI: https://doi.org/10.1016/j.cell.2020.12.017 ...Learn More

GenCRISPR gRNA design tool is a free online tool to design individual gRNA and gRNA library. It employs a newly-developed algorithm which integrates the design instructions from the latest progress and expertise. With GenCRISPR gRNA design tool, you can design gRNAs target either ...Learn More

The CRISPR-Cas9 system has revolutionised gene-editing, but cutting DNA isn’t all it can do. From turning gene expression on and off to fluorescently tagging particular sequences, this animation explores some of the exciting possibilities of CRISPR.

We recently had a short talk with MolecularCloud excellent writer Dr. Miguel Fontela, who spoke about top 3 tips of scientific writing and pointed out that one needs to be flexible about timing and multitasking during one’s doctoral period.

Fusion oncogenes are strong driven factor for tumor progress, which only express in cancer cell. Researchers observed that eliminating directionally fusion oncogenes where the cancer induced by that, giving rise to apoptosis of cancer cells. Though this therapeutic target is very ...Learn More