Hello everyone! I have successfully joined Cloud Scientist program！ I’m Xueli Zhang, a Principal Investigator of the Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences. My research focuses on constructing microbial cell factories for production of bulk ...Learn More

Bacteriophages (also known as ‘phages’), which are viruses that infect bacteria, are the most abundant biological entities on the planet [1]. As a response to the constant threat of phage infection, a huge arsenal of defense mechanisms has evolved in bacterial hosts, and as a ...Learn More

MulticopyChromosomal Integration Using CRISPR-Associated TransposasesControlling the copy number of gene expression cassettes is an important strategy to engineer bacterial cells into high-efficiency biocatalysts. Current strategies mostly use plasmid vectors, but multicopy ...Learn More

Current base-editing techniques can only facilitate C-to-T editing and A-to-G editing, so a complete base-editing technique for converting any base to any other base is highly desirable. On July 20, 2020, Dr. Changhao Bi’s team and Dr. Xueli Zhang’s team at Tianjin Institute ...Learn More

Are you still thinking that CRISPR-Cas system is only used for cutting DNA in fragments to generate knock out models? If you answered ‘yes’, then join us in a quick trip through a new landscape of applications and opportunities.Nowadays, when talking about CRISPR-Cas systems, ...Learn More