Changhao Bi

Dr. Changhao Bi received his doctoral degree in Microbiology and Cell Science from the University of Florida. He had completed postdoctoral research at the University of Delaware and at The Joint BioEnergy Institute (JBEI), Lawrence Berkeley National Laboratory. Dr. Bi is currently a Principal Investigator and Professor at the Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences. Dr. Bi’s research focuses on developing of cellular bio-factories by metabolically engineering bacterial strains. Recently his focus has been to develop and optimize CRISPR based systems. Such developments include an electroporation-based CRISPR system and a gRNA-free CRISPR system for PAM-free/CRISPR-tolerant gene regions. Both have applications to develop bioengineered strains. From these cellular bio-factories, Dr. Bi aims to create products including chemical feedstock, biofuels, and natural medical products.

Lab Information

Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences

Research Area and Skills

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Biological Engineering 2 CRISPR / Cas9 3 DNA Extraction 0 DNA Purification 0 Gene Editing 1 Gene Knock-In 1 Gene Knock-Out 1 Microbial Biotechnology 0 Molecular Cloning 1

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We are glad that so many people are interested in our recent research " Glycosylase base editors enable C-to-A and C-to-G base changes " and our shared plasmids. On October 21st, I had a conversation with GenScript team about the future insights of synthetic biology and genome ...Learn More


  1. Zhao, D., Li, J., Li, S., Xin, X., Hu, M., Price, M. A., ... & Zhang, X. (2020). Glycosylase base editors enable C-to-A and C-to-G base changes. Nature Biotechnology.

  2. Li, Z., Xiong, B., Liu, L., Li, S., Xin, X., Li, Z., Zhang, X, Bi, C. (2019). Development of an autotrophic fermentation technique for the production of fatty acids using an engineered Ralstonia eutropha cell factory. Journal of industrial microbiology & biotechnology, 1-8.

  3. Feng, X., Zhao, D., Zhang, X., Ding, X., Bi, C. (2018). CRISPR/Cas9 assisted Multiplex Genome Editing Technique in Escherichia coli. Biotechnology journal, 1700604.

  4. Zhao, D., Feng, X., Zhu, X., Wu, T., Zhang, X., Bi, C. (2017). CRISPR/Cas9-assisted gRNA-free one-step genome editing with no sequence limitations and improved targeting efficiency. Scientific Reports, 16624.


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